货号 (SKU)

包装规格

是否现货

价格

数量

Ab170578-100μg

100μg

现货

Ab170578-1mg

1mg

现货

Ab170578-5mg

5mg

现货

Ab170578-10mg

10mg

期货

基本信息

产品名称	Oleclumab (anti-CD73), 外-5'-核苷酸酶抗体
别名	奥利珠单抗（抗 CD73）
英文别名	5'-NT \| EC 3.1.3.5 \| Ecto-5'-nucleotidase
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	NT5E
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	外-5'-核苷酸酶抗体

产品属性

抗体类型	Primary antibody
克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	lambda
SDS-PAGE	28.1 kDa (Light Chain) & 50.0 kDa (Heavy Chain), under reducing conditions; 172.2 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1803176-05-7
分子类型	抗体

关联靶点（人）

NT5E Tchem 5'-核苷酸酶(5'-nucleotidase) (0 活性数据)

点击查看靶蛋白信息： NT5E

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Flow Cytometry: Oleclumab (anti-CD73) (Ab170578)

Oleclumab (anti-CD73) (Ab170578) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling CD73 (red) with Oleclumab (anti-CD73) (Ab170578). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Oleclumab (anti-CD73) (Ab170578)

Oleclumab (anti-CD73) (Ab170578) - SEC
The purity of Oleclumab (anti-CD73) (Ab170578) is more than 95% verified by HPLC.

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到5个结果

批号(Lot Number)	证书类型	货号
ZJ23F1201923	分析证书	Ab170578
ZJ23F1201924	分析证书	Ab170578
ZJ24F1214817	分析证书	Ab170578
ZJ24F1214816	分析证书	Ab170578
ZJ24F1214815	分析证书	Ab170578

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引用文献

1. Geoghegan JC, Diedrich G, Lu X, Rosenthal K, Sachsenmeier KF, Wu H, Dall'Acqua WF, Damschroder MM. (2016) Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action.. MAbs, 8 (3): (454-67). [PMID:26854859]
2. Hay CM, Sult E, Huang Q, Mulgrew K, Fuhrmann SR, McGlinchey KA, Hammond SA, Rothstein R, Rios-Doria J, Poon E et al.. (2016) Targeting CD73 in the tumor microenvironment with MEDI9447.. Oncoimmunology, 5 (8): (e1208875). [PMID:27622077]
3. Eliahu S, Lecka J, Reiser G, Haas M, Bigonnesse F, Lévesque SA, Pelletier J, Sévigny J, Fischer B.. (2010) Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.. J Med Chem, 53 (24): (8485-8497). [PMID:21090681] [10.1021/jm100597c]
4. al-Rashida M, Raza R, Abbas G, Shah MS, Kostakis GE, Lecka J, Sévigny J, Muddassar M, Papatriantafyllopoulou C, Iqbal J.. (2013) Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.. Eur J Med Chem, 66 (438-449). [PMID:23831808] [10.1016/j.ejmech.2013.06.015]
5. Gillerman I, Lecka J, Simhaev L, Munkonda MN, Fausther M, Martín-Satué M, Senderowitz H, Sévigny J, Fischer B.. (2014) 2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor.. J Med Chem, 57 (14): (5919-5934). [PMID:24972256] [10.1021/jm401933c]
6. Lee SY, Perotti A, De Jonghe S, Herdewijn P, Hanck T, Müller CE.. (2016) Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors.. Bioorg Med Chem, 24 (14): (3157-3165). [PMID:27265686] [10.1016/j.bmc.2016.05.046]
7. Abdel-Magid AF.. (2017) Inhibitors of CD73 May Provide a Treatment for Cancer and Autoimmune Diseases.. ACS Med Chem Lett, 8 (8): (781-782). [PMID:28835785] [10.1021/acsmedchemlett.7b00255]
8. Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA.. (2019) Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.. J Med Chem, 62 (7): (3677-3695). [PMID:30895781] [10.1021/acs.jmedchem.9b00164]
9. Du X,Moore J,Blank BR,Eksterowicz J,Sutimantanapi D,Yuen N,Metzger T,Chan B,Huang T,Chen X,Chen Y,Duong F,Kong W,Chang JH,Sun J,Zavorotinskaya T,Ye Q,Junttila MR,Ndubaku C,Friedman LS,Fantin VR,Sun D. (2020) Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production.. J Med Chem, 63 (18): (10433-10459). [PMID:32865411] [10.1021/acs.jmedchem.0c01086]
10. Misumi, Y Y, Ogata, S S, Ohkubo, K K, Hirose, S S and Ikehara, Y Y.. (1990) Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.. European journal of biochemistry, (17): [PMID:2129526]
11. Klemens, M R MR and 5 more authors.. (1990) Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.. Biochemical and biophysical research communications, (15): [PMID:2173922]
12. Hansen, K R KR, Resta, R R, Webb, C F CF and Thompson, L F LF.. (1995) Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene.. Gene, (29): [PMID:8566797]
13. Otsuki, Tetsuji T and 24 more authors.. (2005) Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.. DNA research : an international journal for rapid publication of reports on genes and genomes, [PMID:16303743]
14. Ustunsoy, Hasim H and 5 more authors.. The effects of pentoxifylline on the myocardial inflammation and ischemia-reperfusion injury during cardiopulmonary bypass.. Journal of cardiac surgery, [PMID:16426349]
15. Wollscheid, Bernd B and 7 more authors.. (2009) Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.. Nature biotechnology, [PMID:19349973]
16. St Hilaire, Cynthia C and 20 more authors.. (2011) NT5E mutations and arterial calcifications.. The New England journal of medicine, (3): [PMID:21288095]
17. Garavaglia, Silvia S and 9 more authors.. (2012) The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism.. The Biochemical journal, (1): [PMID:21933152]
18. Heuts, Dominic P H M DP and 6 more authors.. (2012) Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity.. Chembiochem : a European journal of chemical biology, (5): [PMID:22997138]
19. Knapp, Karen K and 5 more authors.. (2012) Crystal structure of the human ecto-5'-nucleotidase (CD73): insights into the regulation of purinergic signaling.. Structure (London, England : 1993), (5): [PMID:23142347]
20. Fausther, Michel M, Lavoie, Elise G EG, Goree, Jessica R JR, Baldini, Giulia G and Dranoff, Jonathan A JA.. (2014) NT5E mutations that cause human disease are associated with intracellular mistrafficking of NT5E protein.. PloS one, [PMID:24887587]
21. Channar, Pervaiz Ali PA and 8 more authors.. (2017) Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto-5'-nucleotidase.. Chemical biology & drug design, [PMID:27589035]

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Oleclumab (anti-CD73), 外-5'-核苷酸酶抗体

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Oleclumab (anti-CD73), 外-5'-核苷酸酶抗体

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