基本信息

产品名称	Recombinant NAK/TBK1 Antibody
别名	TANK结合激酶1抗体 \| TANK结合激酶1单克隆抗体 \| TANK结合激酶1重组单克隆抗体 \| NF-κB活化激酶抗体 \| NF-κB活化激酶单克隆抗体 \| NF-κB活化激酶重组单克隆抗体 \| NAK抗体 \| NAK单克隆抗体 \| NAK重组单克隆抗体 \| TBK1抗体 \| TBK1单克隆抗体 \| TBK1重组单克隆抗体
英文别名	EC 2.7.11.1 antibody \| FLJ11330 antibody \| FTDALS4 antibody \| NAK antibody \| NF kappa B activating kinase antibody \| NF kB activating kinase antibody \| NF-kappa-B-activating kinase antibody \| Serine/threonine protein kinase TBK 1 antibody \| Serine/threoni
规格或纯度	重组, ExactAb™, 已验证, 见COA
生化机理	Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.
宿主种属	兔(Rabbit)
特异性	NAK/TBK1
种属反应性	人(Human),大鼠(Rat),小鼠(Mouse)
免疫原	A synthetic peptide derived from human NAK/TBK1 (AA 1-39)
阳性对照	WB: MCF7, SK-OV-3, K562, HeLa, Hep G2, Jurkat, NIH/3T3 and C6 cell lysates. IHC: Human testis tissue. ICC/IF: MCF7 cells.
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Rabbit IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
物理外观	Liquid
储存缓冲液	10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4
防腐剂	0.02% Sodium azide
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4℃ 短期储存（1-2 周）。-20℃长期保存（24 个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

TBK1 Tchem 丝氨酸/苏氨酸蛋白激酶 TBK1(Serine/threonine-protein kinase TBK1) (0 活性数据)

点击查看靶蛋白信息： TBK1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

TBK1 Tchem Serine/threonine-protein kinase TBK1 (3746 活性数据)

点击查看靶蛋白信息： TBK1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

TBK1 Tchem von Hippel-Lindau disease tumor suppressor/Serine/threonine-protein kinase TBK1 (77 活性数据)

点击查看靶蛋白信息： TBK1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

图片

Western Blot: Recombinant NAK/TBK1 Antibody (Ab117042)

Recombinant NAK/TBK1 Antibody (Ab117042) - Western Blot
All lanes: Recombinant NAK/TBK1 Antibody (Ab117042) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 84 kDa
Observed band size: 84 kDa
Exposure time: 7.3 s

IHC: Recombinant NAK/TBK1 Antibody (Ab117042)

Recombinant NAK/TBK1 Antibody (Ab117042) - IHC
Immunohistochemistry analysis of paraffin-embedded Human testis using Recombinant NAK/TBK1 Antibody (Ab117042). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

IF/ICC: Recombinant NAK/TBK1 Antibody (Ab117042)

Recombinant NAK/TBK1 Antibody (Ab117042) - IF/ICC
Immunofluorescence analysis of TBK1 in MCF7 using Recombinant NAK/TBK1 Antibody (Ab117042).

应用

应用名称	稀释比例
IF/ICC	1/50-1/200
IHC	1/100 - 1/200
WB	1/1000 - 1/2000

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批号(Lot Number)	证书类型	货号
ZJ25F0420584	分析证书	Ab117042
ZJ25F0420585	分析证书	Ab117042
ZJ25F0420583	分析证书	Ab117042
ZJ25F0319273	分析证书	Ab117042
ZJ24F0505544	分析证书	Ab117042
ZJ24F0505545	分析证书	Ab117042