货号 (SKU)

包装规格

是否现货

价格

数量

Ab088433-10μl

10μl

现货

Ab088433-50μl

50μL

现货

Ab088433-100μl

100μL

期货

Ab088433-1ml

1ml

期货

基本信息

产品名称	Recombinant Alpha Skeletal Muscle Actin Antibody
别名	ACTA1抗体 \| 肌动蛋白α1抗体 \| 骨骼肌肌动蛋白α1抗体 \| 重组 Alpha 骨骼肌肌动蛋白抗体
英文别名	a actin antibody \| ACTA antibody \| ACTA1 antibody \| Actin, alpha skeletal muscle antibody \| ACTS_HUMAN antibody \| Alpha actin 1 antibody \| Alpha-actin-1 antibody \| ASMA antibody \| MPFD antibody \| Skeletal muscle alpha actin 1 antibody \| ACTA1 \| ACTA \| Act
规格或纯度	重组, ExactAb™, 已验证, 高性能, 见COA
生化机理	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
宿主种属	兔(Rabbit)
特异性	Alpha Skeletal Muscle Actin
种属反应性	人(Human),大鼠(Rat),小鼠(Mouse),鸡(Chicken)
免疫原	A synthetic peptide derived from human Alpha Skeletal Muscle Actin (AA 40-85).
阳性对照	WB: Mouse spleen, Rat heart, HeLa, A431, HEK293, NIH/3T3 and C6 lysates. IHC: Mouse heart tissue. IF/ICC: HeLa cells.
偶联	Unconjugated

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Rabbit IgG
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
物理外观	Liquid
储存缓冲液	10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4.
防腐剂	0.02% Sodium azide
浓度	见COA
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。
分子类型	抗体

关联靶点（人）

ACTA1 Tbio 肌动蛋白，α骨骼肌(Actin, alpha skeletal muscle) (0 活性数据)

点击查看靶蛋白信息： ACTA1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

图片

Western Blot: Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433)

Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) - Western Blot
All lanes: Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) at 1/20000 dilution

Predicted band size: 42 kDa
Observed band size: 42 kDa
Exposure time: 3.8 s

IF/ICC: Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433)

Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) - IF/ICC
Immunofluorescent analysis of HeLa cells using Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433).

IF/ICC: Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433)

Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) - IF/ICC
Immunofluorescent analysis of HeLa cells using Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) at 1/50 dilution.

IF/ICC: Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433)

Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) - IF/ICC
Immunofluorescent analysis of HeLa cells using Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) at 1/50 dilution.

IHC: Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433)

Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433) - IHC
Immunohistochemical analysis of paraffin-embedded mouse heart, using Recombinant Alpha Skeletal Muscle Actin Antibody (Ab088433).

应用

应用名称	稀释比例
WB	1/1000 - 1/10000
IHC	1/100-1/500
IF/ICC	1/50-1/500

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到2个结果

批号(Lot Number)	证书类型	货号
ZJ24F1012484	分析证书	Ab088433
ZJ24F1012485	分析证书	Ab088433

引用文献

1. Taylor, A A, Erba, H P HP, Muscat, G E GE and Kedes, L L.. (1988) Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains.. Genomics, [PMID:2907503]
2. Hanauer, A A and 5 more authors.. (1983) Isolation and characterization of cDNA clones for human skeletal muscle alpha actin.. Nucleic acids research, (11): [PMID:6190133]
3. Nowak, K J KJ and 24 more authors.. (1999) Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy.. Nature genetics, [PMID:10508519]
4. Hauser, M A MA and 17 more authors.. (2000) Myotilin is mutated in limb girdle muscular dystrophy 1A.. Human molecular genetics, (1): [PMID:10958653]
5. Jungbluth, H H and 10 more authors.. (2001) Mild phenotype of nemaline myopathy with sleep hypoventilation due to a mutation in the skeletal muscle alpha-actin (ACTA1) gene.. Neuromuscular disorders : NMD, [PMID:11166164]
6. Ilkovski, B B and 15 more authors.. (2001) Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene.. American journal of human genetics, [PMID:11333380]
7. Sparrow, John C JC and 7 more authors.. (2003) Muscle disease caused by mutations in the skeletal muscle alpha-actin gene (ACTA1).. Neuromuscular disorders : NMD, [PMID:12921789]
8. Ilkovski, Biljana B and 8 more authors.. (2004) Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms.. Human molecular genetics, (15): [PMID:15198992]
9. Agrawal, Pankaj B PB and 11 more authors.. (2004) Heterogeneity of nemaline myopathy cases with skeletal muscle alpha-actin gene mutations.. Annals of neurology, [PMID:15236405]
10. Ohlsson, M M, Tajsharghi, H H, Darin, N N, Kyllerman, M M and Oldfors, A A.. (2004) Follow-up of nemaline myopathy in two patients with novel mutations in the skeletal muscle alpha-actin gene (ACTA1).. Neuromuscular disorders : NMD, [PMID:15336687]
11. Laing, Nigel G NG and 12 more authors.. (2004) Actin mutations are one cause of congenital fibre type disproportion.. Annals of neurology, [PMID:15468086]
12. Kaindl, A M AM and 11 more authors.. (2004) Missense mutations of ACTA1 cause dominant congenital myopathy with cores.. Journal of medical genetics, [PMID:15520409]
13. Hutchinson, David O DO, Charlton, Amanda A, Laing, Nigel G NG, Ilkovski, Biljana B and North, Kathryn N KN.. (2006) Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: clinical and pathological variability within a kindred.. Neuromuscular disorders : NMD, [PMID:16427282]
14. Bosch-Comas, A A, Lindsten, K K, Gonzàlez-Duarte, R R, Masucci, M G MG and Marfany, G G.. (2006) The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.. Cellular and molecular life sciences : CMLS, [PMID:16501887]
15. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414]
16. D'Amico, Adele A and 14 more authors.. (2006) Fatal hypertrophic cardiomyopathy and nemaline myopathy associated with ACTA1 K336E mutation.. Neuromuscular disorders : NMD, [PMID:16945537]
17. Clarke, Nigel F NF and 8 more authors.. (2007) The pathogenesis of ACTA1-related congenital fiber type disproportion.. Annals of neurology, [PMID:17387733]
18. Domazetovska, Ana A and 10 more authors.. (2007) Intranuclear rod myopathy: molecular pathogenesis and mechanisms of weakness.. Annals of neurology, [PMID:17705262]
19. Kudryashov, Dmitri S DS and 10 more authors.. (2008) Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.. Proceedings of the National Academy of Sciences of the United States of America, (25): [PMID:19015515]
20. Peng, Chao C and 18 more authors.. (2011) The first identification of lysine malonylation substrates and its regulatory enzyme.. Molecular & cellular proteomics : MCP, [PMID:21908771]
21. Jain, R K RK and 14 more authors.. (2012) Nemaline myopathy with stiffness and hypertonia associated with an ACTA1 mutation.. Neurology, (3): [PMID:22442437]
22. Gatayama, Ryohei R and 6 more authors.. (2013) Nemaline myopathy with dilated cardiomyopathy in childhood.. Pediatrics, [PMID:23650303]
23. Li, Ming-Ming MM and 18 more authors.. (2013) ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.. Nature communications, [PMID:23673617]
24. Chae, Jong Hee JH and 6 more authors.. (2015) Utility of next generation sequencing in genetic diagnosis of early onset neuromuscular disorders.. Journal of medical genetics, [PMID:25635128]
25. Zukosky, Kristen K and 22 more authors.. (2015) Association of a Novel ACTA1 Mutation With a Dominant Progressive Scapuloperoneal Myopathy in an Extended Family.. JAMA neurology, [PMID:25938801]
26. Heisler, David B and 10 more authors.. (2015) ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.. Science (New York, N.Y.), (31): [PMID:26228148]
27. Ahmed, Atif A AA and 7 more authors.. (2018) Arthrogryposis and pterygia as lethal end manifestations of genetically defined congenital myopathies.. American journal of medical genetics. Part A, [PMID:29274205]
28. Wilkinson, Alex W AW and 21 more authors.. (2019) SETD3 is an actin histidine methyltransferase that prevents primary dystocia.. Nature, [PMID:30626964]

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稀释计算器

计算配制储备溶液所需的稀释度。

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复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Recombinant Alpha Skeletal Muscle Actin Antibody

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Recombinant Alpha Skeletal Muscle Actin Antibody

库存信息

库存信息

库存信息

库存信息

基本信息

产品属性

关联靶点（人）

图片

应用

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器