Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab182865-100μg
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100μg |
10
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$89.90
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Ab182865-1mg
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1mg |
4
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$449.90
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Ab182865-5mg
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5mg |
1
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$989.90
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Ab182865-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,599.90
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Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Vixarelimab (anti-OSMR) - Primary antibody, specific to OSMR, Human IgG4SP, INHIBITOR of Oncostatin-M-specific receptor subunit beta inhibitor |
|---|---|
| Synonyms | IL-31 receptor subunit beta antibody | IL-31R subunit beta antibody | IL-31R-beta antibody | IL-31RB antibody | Interleukin-31 receptor subunit beta antibody | MGC140467 antibody | MGC150626 antibody | MGC150627 antibody | MGC75127 antibody | Oncostatin M |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | OSMR |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Oncostatin-M-specific receptor subunit beta inhibitor |
| Product Description |
Vixarelimab (anti-OSMR) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab (anti-OSMR) can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash. |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 145 kDa |
| Purification Method | Protein A purified |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2243320-83-2 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Vixarelimab (anti-OSMR) (Ab182865) - Flow
HuOSMR-HEK293 cells were stained with Vixarelimab (anti-OSMR) (Ab182865) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC₅₀ is 0.033 μg/mL.
Vixarelimab (anti-OSMR) (Ab182865) - SEC
The purity of Vixarelimab (anti-OSMR) (Ab182865) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jul 24, 2024 | Ab182865 | |
| Certificate of Analysis | Jul 24, 2024 | Ab182865 | |
| Certificate of Analysis | Jul 24, 2024 | Ab182865 |