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Vixarelimab (anti-OSMR) - Primary antibody, specific to OSMR, Human IgG4SP, INHIBITOR of Oncostatin-M-specific receptor subunit beta inhibitor, INHIBITOR of Oncostatin-M-specific receptor subunit beta inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182865
Grouped product items
SKU Size
Availability
Price Qty
Ab182865-100μg
100μg
10
$89.90
Ab182865-1mg
1mg
4
$449.90
Ab182865-5mg
5mg
1
$989.90
Ab182865-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,599.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level≤1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Vixarelimab (anti-OSMR) - Primary antibody, specific to OSMR, Human IgG4SP, INHIBITOR of Oncostatin-M-specific receptor subunit beta inhibitor
Synonyms IL-31 receptor subunit beta antibody | IL-31R subunit beta antibody | IL-31R-beta antibody | IL-31RB antibody | Interleukin-31 receptor subunit beta antibody | MGC140467 antibody | MGC150626 antibody | MGC150627 antibody | MGC75127 antibody | Oncostatin M
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity OSMR
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Oncostatin-M-specific receptor subunit beta inhibitor
Product Description

Vixarelimab (anti-OSMR) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab (anti-OSMR) can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type lambdaC2
SDS-PAGE 145 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2243320-83-2

Associated Targets(Human)

OSMR Tbio Oncostatin-M-specific receptor subunit beta (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Vixarelimab (anti-OSMR) (Ab182865) - Flow
HuOSMR-HEK293 cells were stained with Vixarelimab (anti-OSMR) (Ab182865) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC₅₀ is 0.033 μg/mL.

Vixarelimab (anti-OSMR) (Ab182865) - SEC
The purity of Vixarelimab (anti-OSMR) (Ab182865) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708659 Certificate of Analysis Jul 24, 2024 Ab182865
ZJ24F0708658 Certificate of Analysis Jul 24, 2024 Ab182865
ZJ24F0708657 Certificate of Analysis Jul 24, 2024 Ab182865

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