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Vedolizumab (anti-α4β7-integrin) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to Integrin a4b7 (ITGA4 & ITGB7), >95%, high purity, Human IgG1, Antibody of integrin α4β7, Antibody of integrin α4β7

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab169270
Grouped product items
SKU Size
Availability
Price Qty
Ab169270-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
Ab169270-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$387.90
Ab169270-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$717.90
Ab169270-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,077.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Vedolizumab (anti-α4β7-integrin) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to Integrin a4b7 (ITGA4 & ITGB7), >95%, high purity, Human IgG1, Antibody of integrin α4β7
Synonyms Recombinant Vedolizumab Antibody | Vedolizumab | Entyvio | Anti-Integrin a4b7 (ITGA4 & ITGB7) Reference Antibody (vedolizumab) | Antigen CD49D antibody | CD49d antibody | IA4 antibody | Integrin alpha 4 subunit antibody | Integrin alpha IV antibody | Inte
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity Integrin a4b7 (ITGA4 & ITGB7)
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of integrin α4β7
Product Description

Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.5 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 178.5 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 943609-66-3

Associated Targets(Human)

ITGA4 Tclin Integrin alpha-4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB7 Tclin Integrin beta-7 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGA4 Tclin Integrin alpha-4 (295 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB7 Tclin Integrin beta-7 (3 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Vedolizumab (anti-α4β7-integrin) (Ab169270) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling α4β7-integrin (red) with Vedolizumab (anti-α4β7-integrin) (Ab169270). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG ( Ab170213 ). Black - Unlabelled control, cells without incubation with primary antibody.

Vedolizumab (anti-α4β7-integrin) (Ab169270) - SEC
The purity of Vedolizumab (anti-α4β7-integrin) (Ab169270) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F0800948 Certificate of Analysis Aug 30, 2023 Ab169270
ZJ23F0800947 Certificate of Analysis Aug 30, 2023 Ab169270

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