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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176608-100μg
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100μg |
10
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$129.90
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Ab176608-1mg
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1mg |
4
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$649.90
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Ab176608-5mg
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5mg |
1
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$1,189.90
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|
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Ab176608-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,909.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | TTX-030 (anti-ENTPD1) - Primary antibody, specific to ENTPD1, >95%, high purity, Human IgG4SP |
|---|---|
| Synonyms | EC 3.6.1.5 | Ecto-apyrase | Ecto-ATP diphosphohydrolase 1 | Ecto-ATPase 1 | Ecto-ATPDase 1 | Lymphoid cell activation antigen | NTPDase 1 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ENTPD1 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
TTX-030 (anti-ENTPD1) is a fully human monoclonal antibody directed targeting the cell surface receptor CD39. It specifically binds to the CD39 antigen and inhibits both the conversion of adenosine triphosphate (ATP) to adenosine monophosphate (AMP) and the subsequent generation of immunosuppressive extracellular adenosine in the tumor microenvironment (TME). |
| Isotype | Human IgG4SP |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
TTX-030 (anti-ENTPD1) (Ab176608) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ENTPD1 with TTX-030 (anti-ENTPD1) (Ab176608) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
TTX-030 (anti-ENTPD1) (Ab176608) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling ENTPD1 (red) with TTX-030 (anti-ENTPD1) (Ab176608) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
TTX-030 (anti-ENTPD1) (Ab176608) - SEC
The purity of TTX-030 (anti-ENTPD1) (Ab176608) is more than 95% verified by HPLC.
TTX-030 (anti-ENTPD1) (Ab176608) - ELISA
Immobilized huCD39ECD-chis at 2.0 μg/mL can bind TTX-030 (anti-ENTPD1) (Ab176608) with the EC₅₀ of 6.56 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 08, 2024 | Ab176608 | |
| Certificate of Analysis | Apr 08, 2024 | Ab176608 | |
| Certificate of Analysis | Apr 08, 2024 | Ab176608 |