Determine the necessary mass, volume, or concentration for preparing a solution.
This is a demo store. No orders will be fulfilled.
| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
Ab175667-100μg
|
100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$59.90
|
|
|
Ab175667-1mg
|
1mg |
5
|
$259.90
|
|
|
Ab175667-5mg
|
5mg |
1
|
$749.90
|
|
|
Ab175667-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,189.90
|
|
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Tarextumab (anti-NOTCH3) - Primary antibody, specific to NOTCH3, >95%, high purity, Human IgG2, Antibody of notch receptor 2;Antibody of notch receptor 3 |
|---|---|
| Synonyms | CADASIL antibody | CASIL antibody | NOTC3_HUMAN antibody | Notch 3 antibody | Notch 3 intracellular domain antibody | Notch homolog 3 antibody | Notch3 antibody | CADASIL | CASILneurogenic locus notch homolog protein 3 | Notch (Drosophila) homolog 3 | not |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | NOTCH3 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of notch receptor 2;Antibody of notch receptor 3 |
| Product Description |
Tarextumab (anti-NOTCH3) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab (anti-NOTCH3) shows anti-tumor activity. |
| Isotype | Human IgG2 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.0 kDa (Light Chain) & 48.6 kDa (Heavy Chain), under reducing conditions; 162.7 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1359940-55-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Tarextumab (anti-NOTCH3) (Ab175667) - SEC
The purity of Tarextumab (anti-NOTCH3) (Ab175667) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Dec 13, 2023 | Ab175667 | |
| Certificate of Analysis | Dec 13, 2023 | Ab175667 |