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Tarextumab (anti-NOTCH3) - Primary antibody, specific to NOTCH3, >95%, high purity, Human IgG2, Antibody of notch receptor 2;Antibody of notch receptor 3, Antibody of notch receptor 2;Antibody of notch receptor 3

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab175667
Grouped product items
SKU Size
Availability
Price Qty
Ab175667-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175667-1mg
1mg
5
$259.90
Ab175667-5mg
5mg
1
$749.90
Ab175667-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Tarextumab (anti-NOTCH3) - Primary antibody, specific to NOTCH3, >95%, high purity, Human IgG2, Antibody of notch receptor 2;Antibody of notch receptor 3
Synonyms CADASIL antibody | CASIL antibody | NOTC3_HUMAN antibody | Notch 3 antibody | Notch 3 intracellular domain antibody | Notch homolog 3 antibody | Notch3 antibody | CADASIL | CASILneurogenic locus notch homolog protein 3 | Notch (Drosophila) homolog 3 | not
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity NOTCH3
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of notch receptor 2;Antibody of notch receptor 3
Product Description

Tarextumab (anti-NOTCH3) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab (anti-NOTCH3) shows anti-tumor activity.

Product Properties

Isotype Human IgG2
Light Chain Type kappa
SDS-PAGE 26.0 kDa (Light Chain) & 48.6 kDa (Heavy Chain), under reducing conditions; 162.7 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1359940-55-8

Associated Targets(Human)

NOTCH3 Tchem Neurogenic locus notch homolog protein 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
NOTCH2 Tchem Neurogenic locus notch homolog protein 2 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
NOTCH3 Tchem Neurogenic locus notch homolog protein 3 (57 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MOLT-4 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tarextumab (anti-NOTCH3) (Ab175667) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling NOTCH3 (red) with Tarextumab (anti-NOTCH3) (Ab175667). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tarextumab (anti-NOTCH3) (Ab175667) - SEC
The purity of Tarextumab (anti-NOTCH3) (Ab175667) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1202013 Certificate of Analysis Dec 13, 2023 Ab175667
ZJ23F1202014 Certificate of Analysis Dec 13, 2023 Ab175667

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