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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab209754-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$109.90
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Ab209754-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$509.90
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Ab209754-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
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Ab209754-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,299.90
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | TA136 (anti-MPL) - Primary antibody, specific to MPL, Human IgG1 |
|---|---|
| Synonyms | C MPL antibody | CD110 antibody | mpl antibody | MPLV antibody | Myeloproliferative leukemia protein antibody | Myeloproliferative leukemia virus oncogene antibody | Proto-oncogene c-Mpl antibody | THCYT2 antibody | Thrombopoietin receptor antibody | TPO |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. |
| Host species | Human |
| Specificity | MPL |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
TA136 (anti-MPL) is antibody binds to MPL and recognizes a tertial structure of MPL. It can be potentially used in the treatment of congenital amegakaryocytic thrombocytopenia. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | lambda |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
TA136 (anti-MPL) (Ab209754) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling MPL (red) with TA136 (anti-MPL) (Ab209754) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (Cy5) (Ab175833) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
TA136 (anti-MPL) (Ab209754) - Flow
Flow Cytometry analysis of pLVX-puro-P40238-hu-MPL/TPOR/CD110-FL cells at 1×105 cell/well can bind TA136 (anti-MPL) (Ab209754), with the EC₅₀ is 0.3 nM.
TA136 (anti-MPL) (Ab209754) - SEC
The purity of TA136 (anti-MPL) (Ab209754) is more than 95% verified by HPLC.