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p53 Mouse mAb - Primary antibody, specific to p53, Mouse IgG1

COA COA
    Application:
  • WB
  • Host species: Mouse
  • Reactive species: Human,Rat
  • Isotype: Mouse IgG1
  • Clone Number: D1
  • Conjugation: Unconjugated
In stock
Item Number
Ab119827
Grouped product items
SKU Size
Availability
 Price Qty
Ab119827-10μl
10μl
4
$46.90
Ab119827-50μl
50μl
4
$139.90
Ab119827-100μl
100μl
3
$209.90
Ab119827-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,799.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (D1); Mouse anti Human p53 Antibody; WB; Unconjugated

View related series
Click to view target information: TP53
Accession#:P04637 (5) Gene ID:7157 (5) p53 (5) TP53 (5)

Basic Description

Product Name p53 Mouse mAb - Primary antibody, specific to p53, Mouse IgG1
Synonyms Antigen NY-CO-13 antibody | BCC7 antibody | Cellular tumor antigen p53 antibody | FLJ92943 antibody | LFS1 antibody | Mutant tumor protein 53 antibody | p53 antibody | p53 tumor suppressor antibody | P53_HUMAN antibody | Phosphoprotein p53 antibody | Tp53
Specifications & Purity Carrier Free, ExactAb™, Azide Free, Validated, High Performance, See COA
Host species Mouse
Specificity p53
Immunogen Recombinant p53 expressed in E.coli (AA 133-393).
Positive Control WB: A549, MCF7, HT-29, HeLa and HEK293 cell lysates
Conjugation Unconjugated
Grade Azide Free, Carrier Free, ExactAb™, High Performance, Validated
Product Description

Mouse anti Human p53 Antibody, Monoclonal (D1), could be used for WB and so on.

Application

WB: 0.01-2 µg/mL

Protein Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Product Properties

Isotype Mouse IgG1
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A + Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

TP53 Tchem Cellular tumor antigen p53 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Tumour suppressor p53/oncoprotein Mdm2 (2075 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Tumour suppressor protein p53/Mdm4 (85 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem CREB-binding protein/p53 (3 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem MDM2/MDMX-p53 (27 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53/Death-associated protein kinase 1 (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53/Peptidyl-prolyl cis-trans isomerase D (10 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53/Replication protein A 70 kDa DNA-binding subunit (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

p53 Mouse mAb (Ab119827) - Western Blot
All lanes: p53 Mouse mAb (Ab119827) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab138040) at 1/20000 dilution

Predicted band size: 53 kDa
Observed band size: 50 kDa
Exposure time: 29.1 s

Application

Application Dilution info
WB

0.01-2 µg/mL

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404252 Certificate of Analysis Apr 09, 2024 Ab119827
ZJ23F1101579 Certificate of Analysis Nov 08, 2023 Ab119827
ZJ23F1101578 Certificate of Analysis Nov 08, 2023 Ab119827

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