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OSMI-4 - 97%, high purity , CAS No.2260791-14-6

COA

Grade & Purity:

≥97%

Cas Number: 2260791-14-6
Molecular Weight: 604.09
PubChem CID: 137319721
PubChem SID: 504773493

In stock

Item Number

O414263

Grouped product items
SKU	Size	Availability	Price
O414263-1mg	1mg	7	$185.90
O414263-2mg	2mg	6	$308.90
O414263-5mg	5mg	5	$642.90
O414263-10mg	10mg	4	$939.90
O414263-25mg	25mg	4	$2,115.90
O414263-50mg	50mg	4	$2,919.90
O414263-100mg	100mg	4	$3,909.90

Transferase Inhibitors

View related series

Acyltransferase (66) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells. Targets OGT (Cell-free assay) 3 μM(EC50) In vitro OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology. Cell Research(from reference) Cell lines：HEK293T cells Concentrations：5 μM, 10 μM, 20 μM Incubation Time：2 h, 8 h, 16 h, 24 h

Product Properties

ALogP	3.175
HBD Count	2
Rotatable Bond	12

Names and Identifiers

Pubchem Sid	504773493
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773493
IUPAC Name	ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate
INCHI	InChI=1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1
InChIKey	STPSLAZMEWZDAJ-AREMUKBSSA-N
Smiles	CCOC(=O)CN(CC1=CC=CS1)C(=O)C(C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl
PubChem CID	137319721
Molecular Weight	604.09

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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14 results found

Lot Number	Certificate Type	Date	Item
G2304779	Certificate of Analysis	May 22, 2023	O414263
G2304780	Certificate of Analysis	May 22, 2023	O414263
G2304777	Certificate of Analysis	May 22, 2023	O414263
G2304781	Certificate of Analysis	May 22, 2023	O414263
G2304782	Certificate of Analysis	May 22, 2023	O414263
G2304783	Certificate of Analysis	May 22, 2023	O414263
G2304784	Certificate of Analysis	May 22, 2023	O414263
G2304785	Certificate of Analysis	May 22, 2023	O414263
G2304786	Certificate of Analysis	May 22, 2023	O414263
G2304787	Certificate of Analysis	May 22, 2023	O414263
G2304788	Certificate of Analysis	May 22, 2023	O414263
G2304789	Certificate of Analysis	May 22, 2023	O414263
G2304790	Certificate of Analysis	May 22, 2023	O414263
G2304778	Certificate of Analysis	May 22, 2023	O414263

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Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (165.53 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	100
DMSO(mM) Max Solubility	165.538247612111
Water(mg / mL) Max Solubility	＜1

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