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OSMI-4 - 10mM in DMSO, high purity , CAS No.2260791-14-6

COA

Grade & Purity:

10mM in DMSO

Cas Number: 2260791-14-6
Molecular Weight: 604.09
PubChem CID: 137319721

In stock

Item Number

O422714

Grouped product items
SKU	Size	Availability	Price	Qty
O422714-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$241.90

Transferase Inhibitors

View related series

Compound libraries (12325) Lipid metabolism (1912)

Basic Description

Synonyms	ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells. Targets OGT (Cell-free assay) 3 μM(EC50) In vitro OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology. Cell Research(from reference) Cell lines：HEK293T cells Concentrations：5 μM, 10 μM, 20 μM Incubation Time：2 h, 8 h, 16 h, 24 h

Product Properties

ALogP	3.175
HBD Count	2
Rotatable Bond	12

Names and Identifiers

IUPAC Name	ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate
INCHI	InChI=1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1
InChIKey	STPSLAZMEWZDAJ-AREMUKBSSA-N
Smiles	CCOC(=O)CN(CC1=CC=CS1)C(=O)C(C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl
PubChem CID	137319721
Molecular Weight	604.09

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

DMSO(mg / mL) Max Solubility	100
DMSO(mM) Max Solubility	165.538247612111
Water(mg / mL) Max Solubility	＜1

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