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Neoantimycin - 95%, high purity , CAS No.22862-63-1

1 Citations

COA

Grade & Purity:

≥95%

Cas Number: 22862-63-1
Molecular Weight: 698.76
PubChem CID: 585842

In stock

Item Number

N329566

Grouped product items
SKU	Size	Availability	Price	Qty
N329566-500μg	500μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$341.90

a macrocyclic streptomyces antibiotic

View related series

Amino Acid/Protein Metabolism (1836) DNA Damage (697) G Protein Related (287)

Basic Description

Synonyms	1,4,8,11-Tetraoxacyclopentadecane, neoantimycin deriv. \| 3-(Formylamino)-2-hydroxy-N-[(3S,6S,7R,10S,14R,15R)-14-hydroxy-7,13,13-trimethyl-3-(1-methylethyl)-10-[(1S)-1-methylpropyl]-2,5,9,12-tetraoxo-15-(phenylmethyl)-1,4,8,11-tetraoxacyclopentadec-6-yl]be
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Neoantimycin is a macrocyclic antibiotic isolated from\|Streptomyces\|bacteria. The mechanism of action of Neoantimycin is undescribed in the literature. A closely related compound described as an oxidized-type neoantimycin, prunustatin A, is demonstrated to downregulate grp78 transcription and suppress the expression of the GRP 78 molecular chaperone. This suppression affects the role of GRP 78 in promoting protein folding at the endoplasmic reticulum (ER), and suppresses the pro-resistance enhancement of ER stress response by chemotherapy-resistant tumors. The close structural kinship between prunustatin A and Neoantimycin suggests a similar mechanism of action for Neoantimycin toxicity.

Names and Identifiers

IUPAC Name	N-(15-benzyl-10-butan-2-yl-14-hydroxy-7,13,13-trimethyl-2,5,9,12-tetraoxo-3-propan-2-yl-1,4,8,11-tetraoxacyclopentadec-6-yl)-3-formamido-2-hydroxybenzamide
INCHI	InChI=1S/C36H46N2O12/c1-8-20(4)29-34(45)47-21(5)26(38-31(42)23-15-12-16-24(27(23)40)37-18-39)32(43)49-28(19(2)3)33(44)48-25(17-22-13-10-9-11-14-22)30(41)36(6,7)35(46)50-29/h9-16,18-21,25-26,28-30,40-41H,8,17H2,1-7H3,(H,37,39)(H,38,42)
InChIKey	JIJATTFJYJZEBT-UHFFFAOYSA-N
Smiles	CCC(C)C1C(=O)OC(C(C(=O)OC(C(=O)OC(C(C(C(=O)O1)(C)C)O)CC2=CC=CC=C2)C(C)C)NC(=O)C3=C(C(=CC=C3)NC=O)O)C
Isomeric SMILES	CCC(C)C1C(=O)OC(C(C(=O)OC(C(=O)OC(C(C(C(=O)O1)(C)C)O)CC2=CC=CC=C2)C(C)C)NC(=O)C3=C(C(=CC=C3)NC=O)O)C
Molecular Weight	698.76
Reaxy-Rn	3116939
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3116939&ln=

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3 results found

Lot Number	Certificate Type	Date	Item
D23031235	Certificate of Analysis	Dec 21, 2022	N329566
D23031217	Certificate of Analysis	Dec 21, 2022	N329566
I2222340	Certificate of Analysis	Sep 09, 2022	N329566

Chemical and Physical Properties

Solubility	Soluble in ethanol, methanol, DMF, and DMSO.
Refractive Index	n20D1.58 (Predicted)
Boil Point(°C)	930.35° C at 760 mmHg (Predicted)

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Neoantimycin - 95%, high purity , CAS No.22862-63-1

Basic Description

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Alternative Products

Citations of This Product

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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