Basic Description

Synonyms	(2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)ox
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
Storage Temp	Protected from light,Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Neomycin sulfate is an aminoglycoside antibiotic , used to treat bacteria infections. In vitro Neomycin interacts preferentially with the ribozyme-substrate complex and that this interaction leads to a reduction in the cleavage rate by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. Neomycin effects a conformational change in the structure of trans-activating region (TAR) that can be detected by circular dichroism spectroscopy. Neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (koff) for dissociation of the peptide from the RNA. Neomycin is the most effective aminoglycoside (groove binder) in stabilizing a DNA triple helix. Neomycin stabilizes TAT, as well as mixed base DNA triplexes, better than known DNA minor groove binders (which usually destabilize the triplex) and polyamines. Neomycin shows a preference for stabilization of TAT triplets but can also accommodate CGC(+) triplets. Neomycin induces a concentration- and voltage-dependent partial block from both the cytosolic and luminal faces of the channel. Neomycin has a greater affinity for the luminal site of interaction than the cytosolic site: zero-voltage dissociation constants (Kb(0)) are respectively 210.20 nM and 589.70 nM for luminal and cytosolic block. Neomycin also exhibits voltage-dependent relief of block at holding potentials >+60 mV.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - Class Organooxygen compounds
    - Subclass Carbohydrates and carbohydrate conjugates
      - Level5 Aminosaccharides
        Level6 Aminoglycosides
        Level7 Aminocyclitol glycosides
        Level8 2-deoxystreptamine aminoglycosides
        Level9 4,5-disubstituted 2-deoxystreptamines

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
Class	Organooxygen compounds
Subclass	Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes	Aminosaccharides - Aminoglycosides - Aminocyclitol glycosides - 2-deoxystreptamine aminoglycosides
Direct Parent	4,5-disubstituted 2-deoxystreptamines
Alternative Parents	Disaccharides O-glycosyl compounds Aminocyclitols and derivatives Cyclohexanols Cyclohexylamines Organic sulfuric acids Oxanes Tetrahydrofurans 1,2-aminoalcohols Acetals Oxacyclic compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Primary alcohols Organopnictogen compounds
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	4,5-disubstituted 2-deoxystreptamine - Disaccharide - Glycosyl compound - O-glycosyl compound - Aminocyclitol or derivatives - Cyclohexanol - Cyclohexylamine - Sulfuric acid - Cyclitol or derivatives - Oxane - Cyclic alcohol - Tetrahydrofuran - Organic sulfuric acid or derivatives - Secondary alcohol - 1,2-aminoalcohol - Acetal - Organoheterocyclic compound - Oxacycle - Alcohol - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic nitrogen compound - Amine - Organonitrogen compound - Primary amine - Primary alcohol - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as 4,5-disubstituted 2-deoxystreptamines. These are 2-deoxystreptamine aminoglycosides that a glycosidically linked to a pyranose of furanose unit at the C4- and C5-positions.
External Descriptors	aminoglycoside sulfate salt
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

Pubchem Sid	488188580
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488188580
IUPAC Name	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid
INCHI	InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChIKey	OIXVKQDWLFHVGR-WQDIDPJDSA-N
Smiles	C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
Isomeric SMILES	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O
WGK Germany	3
RTECS	QP4375000
Molecular Weight	908.88 (anhydrous basis)
Reaxy-Rn	25082604
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25082604&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

24 results found

Lot Number	Certificate Type	Date	Item
B2520384	Certificate of Analysis	Jan 06, 2025	N412785
B2520385	Certificate of Analysis	Jan 06, 2025	N412785
B2520388	Certificate of Analysis	Jan 06, 2025	N412785
B2520389	Certificate of Analysis	Jan 06, 2025	N412785
I2420727	Certificate of Analysis	Sep 09, 2024	N412785
I2420723	Certificate of Analysis	Sep 09, 2024	N412785
I2420724	Certificate of Analysis	Sep 09, 2024	N412785
I2420725	Certificate of Analysis	Sep 09, 2024	N412785
I2420726	Certificate of Analysis	Sep 09, 2024	N412785
F2417341	Certificate of Analysis	May 20, 2024	N412785
F2417342	Certificate of Analysis	May 20, 2024	N412785
F2417343	Certificate of Analysis	May 20, 2024	N412785
F2417344	Certificate of Analysis	May 20, 2024	N412785
J2323712	Certificate of Analysis	Sep 27, 2023	N412785
J2323719	Certificate of Analysis	Sep 27, 2023	N412785
J2323717	Certificate of Analysis	Sep 27, 2023	N412785
J2323718	Certificate of Analysis	Sep 27, 2023	N412785
K2228624	Certificate of Analysis	Jul 28, 2022	N412785
A2304108	Certificate of Analysis	Jul 28, 2022	N412785
A2304122	Certificate of Analysis	Jul 28, 2022	N412785
G2321173	Certificate of Analysis	Jul 28, 2022	N412785
K2228561	Certificate of Analysis	Jul 28, 2022	N412785
K2228607	Certificate of Analysis	Jul 28, 2022	N412785
K2228626	Certificate of Analysis	Jul 28, 2022	N412785

Show more⌵

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro Water: 100 mg/mL (140.3 mM); DMSO: Insoluble; Ethanol: Insoluble;
Sensitivity	light & moisture sensitive
Specific Rotation[α]	56° (C=10,H2O)
Molecular Weight	712.700 g/mol
XLogP3
Hydrogen Bond Donor Count	15
Hydrogen Bond Acceptor Count	23
Rotatable Bond Count	9
Exact Mass	712.28 Da
Monoisotopic Mass	712.28 Da
Topological Polar Surface Area	436.000 Å²
Heavy Atom Count	47
Formal Charge	0
Complexity	953.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	19
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Citations of This Product

How to Cite Aladdin Scientific Products? Citations Search

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

=

Concentration

x

Volume

x

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

x

Volume 1 (V1)

=

Concentration 2 (C2)

x

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

=

Mass (in vial)

÷

Desired Reconstitution Concentration

SKU	Size	Availability	Price
N412785-5g	5g	10	$12.90
N412785-25g	25g	7	$46.90
N412785-100g	100g	1	$147.90
N412785-500g	500g	1	$519.90

Neomycin sulfate - 97%, high purity , CAS No.1405-10-3