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Gosuranemab (anti-Tau) - Primary antibody, specific to MAPT, Human IgG4SP, INHIBITOR of Microtubule-associated protein tau inhibitor, INHIBITOR of Microtubule-associated protein tau inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab182784
Grouped product items
SKU Size
Availability
Price Qty
Ab182784-100μg
100μg
10
$69.90
Ab182784-1mg
1mg
4
$339.90
Ab182784-5mg
5mg
1
$869.90
Ab182784-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,479.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Gosuranemab (anti-Tau) - Primary antibody, specific to MAPT, Human IgG4SP, INHIBITOR of Microtubule-associated protein tau inhibitor
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity MAPT
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Microtubule-associated protein tau inhibitor
Product Description

Gosuranemab (anti-Tau) is a humanised IgG4 anti-tau monoclonal antibody. Gosuranemab (anti-Tau) binds to human N-terminal tau residues 15-22. Gosuranemab (anti-Tau) has the potential for the research of alzheimer’s disease (AD).
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 50.9 kDa (Heavy Chain), under reducing conditions; 195.4 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1788032-39-2

Associated Targets(Human)

MAPT Tclin Microtubule-associated protein tau (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MAPT Tclin Microtubule-associated protein tau (95507 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPT Tclin KEAP1/Microtubule-associated protein tau (1 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MAPT Tclin KEAP1/Cullin-3/Microtubule-associated protein tau (13 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Gosuranemab (anti-Tau) (Ab182784) - ELISA
Immobilized N-His-hu flTau (2-441 aa) tag at 2.0 μg/mL can bind Gosuranemab (anti-Tau) (Ab182784) with the EC₅₀ of 2.10 ng/mL.

Gosuranemab (anti-Tau) (Ab182784) - SEC
The purity of Gosuranemab (anti-Tau) (Ab182784) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0505096 Certificate of Analysis May 06, 2024 Ab182784
ZJ24F0505095 Certificate of Analysis May 06, 2024 Ab182784
ZJ24F0505094 Certificate of Analysis May 06, 2024 Ab182784

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