LC-MS Grade Solvents and Reagents

Ultra-Pure Solutions for Mass Spectrometry Precision

Aladdin Scientific provides a comprehensive portfolio of LC-MS grade solvents, reagents, and additives designed for high-sensitivity liquid chromatography–mass spectrometry (LC-MS) applications. Every product in this line is optimized to ensure exceptional purity, low background noise, and lot-to-lot consistency, supporting the stringent demands of modern proteomics, metabolomics, pharmaceutical analysis, and more.

What Is LC-MS Grade?

LC-MS grade refers to ultra-pure materials manufactured specifically for LC-MS and LC-MS/MS workflows. These solvents and reagents are processed to remove non-volatile residues, metal ions, plasticizers, and other trace contaminants that can negatively impact ionization efficiency, baseline stability, or instrument longevity.

Key Benefits of LC-MS Grade Products

·  Ultra-High Purity (≥99.99%)
Ensures minimal interference and accurate mass detection—even at trace levels.

·  Low UV and MS Background
Supports clean baselines and reproducible signal profiles in UV and MS detection modes.

·  Volatile, MS-Compatible Additives
Designed for optimal performance with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources.

·  Batch-Tested Quality Control
Every lot is tested against strict performance criteria including MS background, UV absorbance, and impurity profile. Certificates of Analysis (CoA) are available for download.

LC-MS Grade Product Categories

Solvents:

· LC-MS Grade Acetonitrile

· LC-MS Grade Methanol

· LC-MS Grade Water (ultra-pure, low conductivity)

· LC-MS Grade Isopropanol (IPA)

Reagents & Additives:

· Formic Acid, LC-MS Grade

· Acetic Acid, LC-MS Grade

· Ammonium Formate / Acetate (volatile buffers)

· LC-MS Mobile Phase Modifiers

Sample Prep Tools:

· Protein precipitation solvents

· SPE cartridges compatible with MS

· Detergent-free lysis buffers for proteomics

Applications

· Quantitative Bioanalysis (LC-MS/MS)

· Pharmaceutical Quality Control (GMP/GLP)

· Proteomics and Metabolomics

· Biomarker Discovery

· Environmental and Food Residue Analysis

Why Choose Aladdin Scientific LC-MS Grade?

· Advanced purification and filtration processes

· Ultra-low metal content and background ions

· Certified low UV absorbance at 190–254 nm

· Compatible with all major instrument platforms (Agilent, Thermo, SCIEX, Waters, Bruker)

Documentation & Support

Each LC-MS grade product is supplied with:

· Lot-specific Certificate of Analysis (CoA)

· MS performance specifications

· Usage recommendations for both analytical and preparative workflows

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View all LC-MS Grade