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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab169262-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$179.90
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Ab169262-1mg
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1mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$897.90
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Ab169262-5mg
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5mg |
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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$2,877.90
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Ab169262-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$4,317.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Evinacumab (anti-ANGPTL3) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ANGPTL3, >95%, high purity, Human IgG4SP, INHIBITOR of Angiopoietin-related protein 3 inhibitor |
|---|---|
| Synonyms | Recombinant Evinacumab Antibody | Anti-ANGPTL3 Reference Antibody | Evinacumab | REGN1500 | Evinacumab(anti-ANGPTL3) | ANG 5 antibody | ANG-5 antibody | ANG5 antibody | Angiopoietin 5 antibody | Angiopoietin like 3 antibody | Angiopoietin related protein |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ANGPTL3 |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Angiopoietin-related protein 3 inhibitor |
| Product Description |
Evinacumab is a monoclonal antibody that targets, binds to, and pharmacologically inhibits ANGPTL3, which can act as a complementary agent to other LDL-C lowering regimens for patients aged 12 or older with HoFH. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG4SP |
| Light Chain Type | kappa |
| SDS-PAGE | 27.1 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 177.3 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1446419-85-7 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Evinacumab(anti-ANGPTL3) (Ab169262) - SEC
The purity of Evinacumab(anti-ANGPTL3) (Ab169262) is more than 95% verified by HPLC.
Evinacumab (anti-ANGPTL3) (Ab169262) - ELISA
Immobilized huANGPTL3-chis at 2 μg/mL can bind Evinacumab (anti-ANGPTL3) (Ab169262) with the EC₅₀ of 283.8 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Sep 14, 2023 | Ab169262 | |
| Certificate of Analysis | Sep 14, 2023 | Ab169262 |