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Evinacumab (anti-ANGPTL3) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ANGPTL3, >95%, high purity, Human IgG4SP, INHIBITOR of Angiopoietin-related protein 3 inhibitor, INHIBITOR of Angiopoietin-related protein 3 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG4SP
  • Conjugation: Unconjugated
In stock
Item Number
Ab169262
Grouped product items
SKU Size
Availability
Price Qty
Ab169262-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$179.90
Ab169262-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$897.90
Ab169262-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,877.90
Ab169262-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$4,317.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Evinacumab (anti-ANGPTL3) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to ANGPTL3, >95%, high purity, Human IgG4SP, INHIBITOR of Angiopoietin-related protein 3 inhibitor
Synonyms Recombinant Evinacumab Antibody | Anti-ANGPTL3 Reference Antibody | Evinacumab | REGN1500 | Evinacumab(anti-ANGPTL3) | ANG 5 antibody | ANG-5 antibody | ANG5 antibody | Angiopoietin 5 antibody | Angiopoietin like 3 antibody | Angiopoietin related protein
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ANGPTL3
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Angiopoietin-related protein 3 inhibitor
Product Description

Evinacumab is a monoclonal antibody that targets, binds to, and pharmacologically inhibits ANGPTL3, which can act as a complementary agent to other LDL-C lowering regimens for patients aged 12 or older with HoFH.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG4SP
Light Chain Type kappa
SDS-PAGE 27.1 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 177.3 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1446419-85-7

Associated Targets(Human)

ANGPTL3 Tclin Angiopoietin-related protein 3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Evinacumab(anti-ANGPTL3) (Ab169262) - SEC
The purity of Evinacumab(anti-ANGPTL3) (Ab169262) is more than 95% verified by HPLC.

Evinacumab (anti-ANGPTL3) (Ab169262) - ELISA
Immobilized huANGPTL3-chis at 2 μg/mL can bind Evinacumab (anti-ANGPTL3) (Ab169262) with the EC₅₀ of 283.8 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F0901032 Certificate of Analysis Sep 14, 2023 Ab169262
ZJ23F0901034 Certificate of Analysis Sep 14, 2023 Ab169262

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