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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab177897-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$109.90
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Ab177897-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$519.90
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Ab177897-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,399.90
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Ab177897-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,239.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | DISC-0974 (anti-RGMC) - Primary antibody, specific to HJV, >95%, high purity, Human IgG1 |
|---|---|
| Synonyms | Hemochromatosis type 2 protein | Hemojuvelin BMP coreceptor | RGM domain family member C |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | HJV |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
DISC-0974 (anti-RGMC) is a humanized monoclonal antibody directed against the bone morphogenetic proteins (BMPs) co-receptor hemojuvelin (HJV) with potential to treat anemia of inflammation and other forms of anemia. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.2 kDa (Light Chain) & 50.9 kDa (Heavy Chain), under reducing conditions; 198.0 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
DISC-0974 (anti-RGMC) (Ab177897) - SEC
The purity of DISC-0974 (anti-RGMC) (Ab177897) is more than 95% verified by HPLC.
DISC-0974 (anti-RGMC) (Ab177897) - Flow Cytometry
pLVX-puro-RGMC-HEK293 cells were stained with DISC-0974 (anti-RGMC) (Ab177897) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC50 is 31.00 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Aug 19, 2024 | Ab177897 | |
| Certificate of Analysis | Aug 19, 2024 | Ab177897 |