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CD163 Mouse mAb - Primary antibody, specific to CD163, Mouse IgG

    Application:
  • IHC
  • Host species: Mouse
  • Reactive species: Human
  • Isotype: Mouse IgG
  • Clone Number: YN00466m
  • Conjugation: Unconjugated
In stock
Item Number
Ab094025
Grouped product items
SKU Size
Availability
Price Qty
Ab094025-10μl
10μl
3
$39.90
Ab094025-50μl
50μl
1
$129.90
Ab094025-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$189.90
Ab094025-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,599.90

mAb (YN00466m); Mouse anti Human CD163 Antibody; IHC; Unconjugated

Basic Description

Product Name CD163 Mouse mAb - Primary antibody, specific to CD163, Mouse IgG
Synonyms OTTHUMP00000238618 antibody | OTTHUMP00000238619 antibody | OTTHUMP00000238620 antibody | SCARI1 antibody | Scavenger receptor cysteine rich type 1 protein M130 antibody | sCD163 antibody | Soluble CD163 antibody | C163A_HUMAN antibody | CD 163 antibody |
Specifications & Purity Azide Free, Validated, Carrier Free, 1.0 mg/mL
Host species Mouse
Specificity CD163
Immunogen Peptide
Positive Control IHC: Human liver tissue.
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Mouse anti Human CD163 Antibody, Monoclonal (YN00466m), could be used for IHC and so on.

Application

  • IHC: 1/200

Protein Function

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Product Properties

Isotype Mouse IgG
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -20℃ long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

CD163 Tbio Scavenger receptor cysteine-rich type 1 protein M130 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Images

CD163 Mouse mAb (Ab094025) - IHC
Immunohistochemistry analysis of paraffin-embedded human liver tissue labelling CD163 with CD163 Mouse mAb (Ab094025) at 1/400 dilution. The section was incubated with Ab094025 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.​

Application

Application Dilution info
IHC

1/200

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0606520 Certificate of Analysis Jun 05, 2024 Ab094025
ZJ24F0606519 Certificate of Analysis Jun 05, 2024 Ab094025

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