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Catumaxomab (anti-CD3&EpCAM) - Primary antibody, specific to CD3E; EPCAM, Mouse IgG2a, Antibody of CD3e, Antibody of CD3e

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Mouse; Rat
  • Reactive species: Human,Mouse,Rat
  • Isotype: Mouse IgG2a & Rat IgG2b
  • Conjugation: Unconjugated
In stock
Item Number
Ab175489
Grouped product items
SKU Size
Availability
Price Qty
Ab175489-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
Ab175489-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$559.90
Ab175489-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,399.90
Ab175489-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,239.90

Purity≥90% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Mouse IgG2a & Rat IgG2b; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Catumaxomab (anti-CD3&EpCAM) - Primary antibody, specific to CD3E; EPCAM, Mouse IgG2a, Antibody of CD3e
Synonyms CD3 epsilon antibody | CD3e antibody | CD3e antigen antibody | CD3e antigen epsilon polypeptide (TiT3 complex) antibody | CD3E antigen epsilon polypeptide antibody | CD3E antigen, epsilon subunit antibody | CD3e molecule epsilon antibody | CD3e molecule,
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥90%(SDS-PAGE&SEC-HPLC), See COA
Biochemical and Physiological Mechanisms CD3: The CD3 complex mediates signal transduction. EpCAM: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier
Host species Mouse; Rat
Specificity CD3E; EPCAM
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type CROSS-LINKING AGENT
Mechanism of action Antibody of CD3e
Product Description

Catumaxomab (anti-CD3&EpCAM), a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab (anti-CD3&EpCAM) region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab (anti-CD3&EpCAM) can be used for anti-tumor research, especially epithelial cancers.

Product Properties

Isotype Mouse IgG2a
Light Chain Type Mouse kappa & Rat lambda2b
SDS-PAGE 146.73 kDa
Purification Method Protein A purified
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 509077-98-9

Associated Targets(Human)

EPCAM Tbio Epithelial cell adhesion molecule (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CD3E Tclin T-cell surface glycoprotein CD3 epsilon chain (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CD3E Tclin T cell surface glycoprotein CD3 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Catumaxomab (anti-CD3&EpCAM) (Ab175489) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Catumaxomab (anti-CD3&EpCAM) (Ab175489) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Catumaxomab (anti-CD3&EpCAM) (Ab175489) - ELISA
Immobilized Recombinant Human EpCAM protein (rp170132) at 1.0 μg/mL can bind Catumaxomab (anti-CD3&EpCAM) (Ab175489) with the EC₅₀ of 66.05 ng/mL.

Catumaxomab (anti-CD3&EpCAM) (Ab175489) - SEC
The purity of Catumaxomab (anti-CD3&EpCAM) (Ab175489) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Solution Calculators

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