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Metabolic Disease Targets
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Recombinant Mouse TNF-alpha ProteinSpecies: Mouse Accession #: P06804Expression system: E. coli Protein Tag: No tag Endotoxin Concentration: <0.01 EU/μgBioactivity: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.1 ng/mL.Synonyms: Recombinant Murine Tumor Necrosis Factor alpha (rMuTNF-α) | APC1 protein | Cachectin | Cachetin | DIF | TNF | TNF, mo...
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Recombinant Human TNF-alpha ProteinSpecies: Human Accession #: P01375Expression system: E. coli Protein Tag: No tag Endotoxin Concentration: <0.1 EU/μgBioactivity: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The ED₅₀ for this effect is typically <0.05 ng/mL.Synonyms: APC1 protein | Cachectin | Cachetin | DIF | TNF | TNF, monocyte-derived | TNFA | TNF-A | TNFalpha | TNF-alpha | TNF-a...
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Recombinant Rat TNF-alpha ProteinSpecies: Rat Accession #: P16599Expression system: HEK293 Protein Tag: C-His Endotoxin Concentration: <0.1 EU/μgBioactivity: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D (Catalog # A113142). The EC50 for this effect is typically <5 pg/mL.Synonyms: APC1 protein | Cachectin | Cachetin | RATTNF | DIF | TNF | TNF, monocyte-derived | TNFA | TNF-A | TNFalpha | TNF-alph...
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Recombinant Mouse FGF-21 ProteinSpecies: Mouse Accession #: Q9JJN1Expression system: E. coli Protein Tag: No tag Endotoxin Concentration: <0.1 EU/μgBioactivity: Fully biologically active when compared to standard. The ED₅₀ as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/ml, corresponding to a specific activity of >2.0 ×10³IU/mg in the presence of 5 µg/ml of rMuβ-Klotho and 10 μg/ml of heparin.Synonyms: FGF21 | FGF-21 | fibroblast growth factor 21 | FGF 21 | FGF21_HUMAN | FGFL | PRO10196 | UNQ3115 | Fgf8c
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Recombinant Mouse TRANCE/RANKL/TNFSF11 ProteinSpecies: Mouse Accession #: O35235Expression system: HEK293 Protein Tag: N-Met & Fc Endotoxin Concentration: <0.01 EU/μgBioactivity: Measured by its ability to induce TRAP activity in Raw 264.7 cells.The ED50 of each lot is between 2-10 ng/mL.Synonyms: CD254 antigen | CD254 | ODF | OPGL | OPGLOPTB2 | Osteoclast differentiation factor | Osteoprotegerin ligand | RANK L ...
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Recombinant Human FGF19 ProteinSpecies: Human Accession #: O95750Expression system: E. coli Protein Tag: N-His Endotoxin Concentration: <1.0 EU/μgBioactivity: FGF19 is a member of the fibroblast growth factor (FGF) family. FGFs are heparin-binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. In general, FGFs are expressed during embryonic development and in restricted adult tissues. Human FGF-19 cDNA predicts a 251 aa precursor protein with a 22 aa signal peptide and a 229 aa secreted mature protein with no potential N-linked glycosylation sites. FGF19-FGFR1 is one of paired transcripts mediating the dialogues between extraembryonic membrane and endometrium. A functional binding ELISA assay was conducted to detect the interaction of Recombinant Human FGF19 Protein (rp145934) and recombinant human FGFR1, the EC50 for this effect is 0.16 μg/mL.Synonyms: FGF19 | FGF-19 | fibroblast growth factor 19 | FGF 19 | FGF15 | FGF19_HUMAN | Fibroblast growth factor 15 | FGF-19
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Recombinant Human IL-1 beta ProteinSpecies: Human Accession #: P01584Expression system: E. coli Protein Tag: C-His Endotoxin Concentration: <1.0 EU/μgBioactivity: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.217-0.870 ng/mL.Synonyms: catabolin | IL1 beta | IL-1 beta | IL-1 | IL1B | IL-1b | IL1-BETA | IL-1F2 | IL1F2IL-1 beta | interleukin 1, beta | i...
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Recombinant Human IFN-alpha/beta R1 ProteinSpecies: Human Accession #: P17181Expression system: HEK293 Protein Tag: C-His Endotoxin Concentration: <0.1 EU/μgBioactivity: Measured by its binding ability in a functional ELISA. When Recombinant Human IFN-alpha / beta R1 is present at 10 μg/mL, it binds to Recombinant Human IFN‑ alpha / beta R2 Fc Chimera in the presence of recombinant human IFN-alpha 2. The concentration of Recombinant Human IFN-alpha / beta R2 Fc Chimera that produces 50% of the optimal binding response is approximately 0.5-1.5 μg/mL.Synonyms: alpha-type antiviral protein; AVP; beta-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine...
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Recombinant Human Arginase 1/ARG1 ProteinSpecies: Human Accession #: P05089-1Expression system: HEK293 Protein Tag: C-His Endotoxin Concentration: <0.1 EU/μgBioactivity: Measured by the production of urea during the hydrolysis of arginine. The specific activity is >27833 pmol/min/μg.Synonyms: AI | ARG1 | Arginase 1 | Arginase, liver | Arginase-1 | EC 3.5.3.1 | Liver Arginase | Liver-type arginase | PGIF | Ty...
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Recombinant Human IFN-gamma R1 ProteinSpecies: Human Accession #: P15260-1Expression system: HEK293 Protein Tag: C-His Endotoxin Concentration: <0.1 EU/μgBioactivity: Immobilized Human FNGR1/CD119 at 1 μg/mL (100 μL/well) can bind Human IFNG with a linear range of 0.98-1.97 ng/mL.Synonyms: AVP, type 2; CD119 antigen; CD119; FLJ45734; IFN-gamma R1; IFN-gamma receptor 1; IFNgammaR1; IFN-gamma-R1; IFNGR; IFN...
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Recombinant Human TNF-α ProteinSpecies: Human Accession #: P01375Expression system: E. coli Protein Tag: N-His Endotoxin Concentration: <1.0 EU/μgBioactivity: Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 20-100 pg/mL.Synonyms: Cachectin | TNF-a | TNF-alpha | Tumor necrosis factor ligand superfamily member 2 | APC1 | APC1 protein | Cachectin |...
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Recombinant Mouse TGF-beta 1 ProteinSpecies: Mouse Accession #: P04202Expression system: HEK293 Protein Tag: N-8His Endotoxin Concentration: <0.1 EU/μgBioactivity: Recombinant Mouse TGF-beta 1 inhibits the IL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.02-0.1 ng/ml.Synonyms: Transforming Growth Factor beta 1 | CEDLAP | DPD1 | latency-associated peptide | TGF beta | TGF beta1 | TGFB | TGFB1 ...
