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Protein Degrader Building Blocks

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  1. , 11-beta-hydroxysteroid dehydrogenase inhibitor
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    Carbenoxolone, 11-beta-hydroxysteroid dehydrogenase inhibitor
    Cas Number: 5697-56-3
    Formula:  C34H50O7        Molecular Weight: 570.76
    IUPAC Name:  (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-show more
    SMILES:  CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(=O)O)OC(=O)CCC(=O)O
    InChIKey: OBZHEBDUNPOCJG-WBXJDKIVSA-N
    InChI:  InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h1show more
    Synonyms: Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3ß,20ß)- | Olean-12-en-30-oic acid, 3ß-hydroxy-11-oxo-,...
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  2. , Antagonist of α 1D-adrenoceptor;Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor
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    Labetalol, Antagonist of α 1D-adrenoceptor;Antagonist of β 1-adrenoceptor;Antagonist of β 2-adrenoceptor
    Cas Number: 36894-69-6
    Formula:  C19H24N2O3        Molecular Weight: 328.41
    IUPAC Name:  2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide
    SMILES:  CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O
    InChIKey: SGUAFYQXFOLMHL-UHFFFAOYSA-N
    InChI:  InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)
    Synonyms: LABETALOL [VANDF] | NINDS_000474 | BRD-A07440155-003-05-6 | DS-4652 | KBio3_002642 | Labetolol | NCGC00015595-12 | NC...
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  3. , Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Channel blocker of CaCC;Gating inhibitor of K ir3.2;Gating inhibitor of K v3.1;Inhibitor of Plasma membrane monoamine transporter;In
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    Fluoxetine, Antagonist of 5-HT 2A receptor;Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 2C receptor;Antagonist of 5-HT 6 receptor;Channel blocker of CaCC;Gating inhibitor of K ir3.2;Gating inhibitor of K v3.1;Inhibitor of Plasma membrane monoamine transporter;In
    Cas Number: 54910-89-3
    Formula:  C17H18F3NO        Molecular Weight: 309.33
    IUPAC Name:  N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
    SMILES:  CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
    InChIKey: RTHCYVBBDHJXIQ-UHFFFAOYSA-N
    InChI:  InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
    Synonyms: (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine | N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propy...
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  5. HTR2C 5 items
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  49. ADRB1 2 items
  50. GFER 2 items
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  53. HTR6 2 items
  54. CYP1B1 1 item
  55. GJA10 1 item
  56. GJA8 1 item
  57. GJA4 1 item
  58. GJB6 1 item
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  60. GJB3 1 item
  61. GJD4 1 item
  62. GJE1 1 item
  63. GJB4 1 item
  64. GJA1 1 item
  65. GJA5 1 item
  66. GJA9 1 item
  67. GJB7 1 item
  68. GJB2 1 item
  69. GJD3 1 item
  70. GJB5 1 item
  71. CYP2C19 1 item
  72. GJD2 1 item
  73. CDK1 1 item
  74. GJA3 1 item
  75. GJC1 1 item
  76. GJC2 1 item
  77. GJC3 1 item
  78. EGLN1 1 item
  79. GABRA1 1 item
  80. NR3C1 1 item
  81. GABRA3 1 item
  82. GABRA5 1 item
  83. DDR2 1 item
  84. F10 1 item
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  86. CCR2 1 item
  87. CCKAR 1 item
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  89. HSD11B2 1 item
  90. HSD11B1 1 item
  91. GABRA2 1 item
  92. CYP2C9 1 item
  93. CDK2 1 item
  94. CRHR1 1 item
  95. DDR1 1 item
  96. PSMB5 1 item
  97. HCRTR1 1 item
  98. SCN2A 1 item
  99. SLC5A8 1 item
  100. S1PR5 1 item
  101. S1PR4 1 item
  102. RNASEH1 1 item
  103. SLC15A1 1 item
  104. SUCNR1 1 item
  105. TYK2 1 item
  106. TYMS 1 item
  107. HRH4 1 item
  108. HSP90AA1 1 item
  109. EPHX2 1 item
  110. HRH3 1 item
  111. HRH2 1 item
  112. HIF1A 1 item
  113. HCAR2 1 item
  114. FAAH 1 item
  115. EPHX1 1 item
  116. HRH1 1 item
  117. JAK3 1 item
  118. TRPV1 1 item
  119. TPH1 1 item
  120. SLC9A1 1 item
  121. SLC5A2 1 item
  122. SCN10A 1 item
  123. SCN3A 1 item
  124. SLC5A1 1 item
  125. SCN4A 1 item
  126. SCN1A 1 item
  127. SCN8A 1 item
  128. SYNJ2 1 item
  129. TRIM24 1 item
  130. TOP1 1 item
  131. THRA 1 item
  132. TTK 1 item
  133. PKN1 1 item
  134. PLK1 1 item
  135. PTGS1 1 item
  136. RARB 1 item
  137. RARA 1 item
  138. PTGS2 1 item
  139. PANX2 1 item
  140. KDM4B 1 item
  141. KDM4C 1 item
  142. KDM6B 1 item
  143. KIF11 1 item
  144. MIF 1 item
  145. MCOLN2 1 item
  146. MCOLN3 1 item
  147. LOXL2 1 item
  148. ALOX5 1 item
  149. LOXL3 1 item
  150. LIPG 1 item
  151. OGG1 1 item
  152. JAK1 1 item
  153. CTSB 1 item
  154. CACNA1I 1 item
  155. CACNA1C 1 item
  156. CTSD 1 item
  157. CA4 1 item
  158. BTK 1 item
  159. CA14 1 item
  160. CYP1A1 1 item
  161. SLC18A2 1 item
  162. ADRB2 1 item
  163. HTR4 1 item
  164. ACKR3 1 item
  165. SCD 1 item
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  167. ADRA2A 1 item
  168. AKR1C3 1 item
  169. ALDH3A1 1 item
  170. ADRA1D 1 item
  171. ALDH1A1 1 item
  172. ALDH2 1 item
  173. APP 1 item
  174. TRIM33 1 item
  175. TAS2R9 1 item
  176. UPP1 1 item
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  178. F2 1 item
  179. ASIC3 1 item
  180. CLK4 1 item
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  184. FOLH1 1 item
  185. IMPDH2 1 item
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  192. NOS2 1 item
  193. NPY5R 1 item
  194. GRIN2B 1 item
  195. JAK2 1 item
  196. KDM3A 1 item
  197. KDM4E 1 item
  198. MAP2K1 1 item
  199. NAALAD2 1 item
  200. NOS1 1 item
  201. PNP 1 item
  202. NOS3 1 item
Purity
  1. ≥97% 1 item
  2. ≥98% 1 item
  3. ≥99% 1 item
Action Type
  1. ANTAGONIST 2 items
  2. INHIBITOR 2 items
  3. CHANNEL BLOCKER 1 item
  4. GATING INHIBITOR 1 item
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