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Transferrin Receptor/CD71 Mouse mAb - Primary antibody, specific to Transferrin Receptor/CD71, Mouse IgG1

COA COA
    Application:
  • Flow Cytometry
  • IP
  • Host species: Mouse
  • Reactive species: Human
  • Isotype: Mouse IgG1
  • Clone Number: T56/14
  • Conjugation: Unconjugated
In stock
Item Number
Ab132241
Grouped product items
SKU Size
Availability
 Price Qty
Ab132241-10μg
10μg
5
$29.90
Ab132241-50μg
50μg
2
$69.90
Ab132241-100μg
100μg
1
$99.90
Ab132241-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$519.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (T56/14); Mouse anti Human Transferrin Receptor/CD71 Antibody; Flow, IP; Unconjugated

View related series
Click to view target information: TFRC
Accession#: P02786 (14) CD71 (21) Flow Cytometry (1158) Gene ID: 7037 (14) Transferrin Receptor (8)

Basic Description

Product Name Transferrin Receptor/CD71 Mouse mAb - Primary antibody, specific to Transferrin Receptor/CD71, Mouse IgG1
Synonyms TFR | IMD46 | CD71 antigen | CD71 | CD71TRFR | p90 | T9 | TfR (Transferrin R) | TfR (TransferrinR) | TfR | TFR1 | TFRC | TR | transferrin receptor (p90, CD71) | transferrin receptor protein 1 | TRFR | CD 71 antibody | CD71 antibody | CD71 antigen antibody
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Mouse
Specificity Transferrin Receptor/CD71
Immunogen Human hematopoietic cell line K562
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Mouse anti Human Transferrin Receptor/CD71 Antibody, Monoclonal (T56/14), could be used for Flow, IP and so on.

Application:
Flow: Use at an assay dependent concentration.

IP: Use at an assay dependent concentration. 
Protein Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.

Product Properties

Isotype Mouse IgG1
Light Chain Type kappa
SDS-PAGE 50 kDa
Purification Method Protein G purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

TFRC Tclin Transferrin receptor protein 1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TFRC Tclin Transferrin receptor protein 1 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Transferrin Receptor/Transferrin Receptor/CD711 Mouse mAb (Ab132241) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 10 μg/mL PHA stimulated 72h (right) human peripheral blood lymphocytes cells labelling Transferrin Receptor/CD71 with Transferrin Receptor/Transferrin Receptor/CD711 Mouse mAb (Ab132241) at 1.0 μg/mL for 1 hour at 4°C conjugated with biotin. SA-PE (rp156150) at a dilution of 1/1000 was used as the secondary antibody.

Transferrin Receptor/Transferrin Receptor/CD711 Mouse mAb (Ab132241) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 10 μg/mL PHA stimulated human peripheral blood lymphocytes cells (72h) labelling Transferrin Receptor/CD71 (red) with Transferrin Receptor/Transferrin Receptor/CD711 Mouse mAb (Ab132241) at 1.0 μg/mL for 1 hour at 4°C conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Mouse IgG (Biotin) (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
IP

Use at an assay dependent concentration.
Flow Cytometry

Use at an assay dependent concentration.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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