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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175677-100μg
|
100μg |
10
|
$69.90
|
|
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Ab175677-1mg
|
1mg |
4
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$339.90
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|
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Ab175677-5mg
|
5mg |
1
|
$869.90
|
|
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Ab175677-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,429.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Tigatuzumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, Antibody of death receptor 5 |
|---|---|
| Synonyms | Fas like protein antibody | Apoptosis inducing protein TRICK2A/2B antibody | Apoptosis inducing receptor TRAIL R2 antibody | CD262 antibody | CD262 antigen antibody | Cytotoxic TRAIL receptor 2 antibody | Death domain containing receptor for TRAIL/Apo 2L |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | TNFRSF10B |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | AGONIST |
| Mechanism of action | Antibody of death receptor 5 |
| Product Description |
Tigatuzumab (anti-TNFRSF10B) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab (anti-TNFRSF10B) induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab (anti-TNFRSF10B) can be used for the research of cancer. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.3 kDa (Light Chain) & 49.8 kDa (Heavy Chain), under reducing conditions; 177.0 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 918127-53-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Tigatuzumab (anti-TNFRSF10B) (
Ab175677
) - ELISA
Immobilized Human TNFRSF10B/TRAILR2/CD262-Fc at 2.0 μg/mL can bind Tigatuzumab (anti-TNFRSF10B) (Ab175677) with the EC₅₀ of 15.36 ng/mL.
Tigatuzumab (anti-TNFRSF10B) (Ab175677) - SEC
The purity of Tigatuzumab (anti-TNFRSF10B) (Ab175677) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 07, 2024 | Ab175677 | |
| Certificate of Analysis | Apr 07, 2024 | Ab175677 | |
| Certificate of Analysis | Apr 07, 2024 | Ab175677 |
Starting at $109.90
Starting at $99.90