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Tigatuzumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, Antibody of death receptor 5, Antibody of death receptor 5

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175677
Grouped product items
SKU Size
Availability
Price Qty
Ab175677-100μg
100μg
10
$69.90
Ab175677-1mg
1mg
4
$339.90
Ab175677-5mg
5mg
1
$869.90
Ab175677-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,429.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Tigatuzumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, Antibody of death receptor 5
Synonyms Fas like protein antibody | Apoptosis inducing protein TRICK2A/2B antibody | Apoptosis inducing receptor TRAIL R2 antibody | CD262 antibody | CD262 antigen antibody | Cytotoxic TRAIL receptor 2 antibody | Death domain containing receptor for TRAIL/Apo 2L
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity TNFRSF10B
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type AGONIST
Mechanism of action Antibody of death receptor 5
Product Description

Tigatuzumab (anti-TNFRSF10B) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab (anti-TNFRSF10B) induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab (anti-TNFRSF10B) can be used for the research of cancer.

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.3 kDa (Light Chain) & 49.8 kDa (Heavy Chain), under reducing conditions; 177.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 918127-53-4

Associated Targets(Human)

TNFRSF10B Tbio Tumor necrosis factor receptor superfamily member 10B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Tigatuzumab (anti-TNFRSF10B) ( Ab175677 ) - ELISA
Immobilized Human TNFRSF10B/TRAILR2/CD262-Fc at 2.0 μg/mL can bind Tigatuzumab (anti-TNFRSF10B) (Ab175677) with the EC₅₀ of 15.36 ng/mL.

Tigatuzumab (anti-TNFRSF10B) (Ab175677) - SEC
The purity of Tigatuzumab (anti-TNFRSF10B) (Ab175677) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0404181 Certificate of Analysis Apr 07, 2024 Ab175677
ZJ24F0404180 Certificate of Analysis Apr 07, 2024 Ab175677
ZJ24F0404179 Certificate of Analysis Apr 07, 2024 Ab175677

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