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Teprotumumab (anti-IGF1R) - Primary antibody, specific to IGF1R, >95%, high purity, Human IgG1, ANTAGONIST of Insulin-like growth factor I receptor antagonist, ANTAGONIST of Insulin-like growth factor I receptor antagonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab170834
Grouped product items
SKU Size
Availability
Price Qty
Ab170834-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab170834-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$267.90
Ab170834-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$687.90
Ab170834-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,077.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Teprotumumab (anti-IGF1R) - Primary antibody, specific to IGF1R, >95%, high purity, Human IgG1, ANTAGONIST of Insulin-like growth factor I receptor antagonist
Synonyms CD221 antibody | CD221 antigen antibody | IGF 1 receptor antibody | IGF 1R antibody | IGF I receptor antibody | IGF-I receptor antibody | Igf1r antibody | IGF1R_HUMAN antibody | IGFIR antibody | IGFIRC antibody | IGFR antibody | Insulin like growth factor
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IGF1R
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action ANTAGONIST of Insulin-like growth factor I receptor antagonist
Product Description

Teprotumumab (anti-IGF1R) is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab (anti-IGF1R) binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab (anti-IGF1R) inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab (anti-IGF1R) attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab (anti-IGF1R) can be used for thyroid-associated ophthalmopathy research.

Purity

>95% (SDS-PAGE&SEC)

Endotoxin Level

< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.6 kDa (Light Chain) & 51.1 kDa (Heavy Chain), under reducing conditions; 178.1 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1036734-93-6

Associated Targets(Human)

IGF1R Tclin Insulin-like growth factor 1 receptor (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Teprotumumab (anti-IGF1R) (Ab170834) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling IGF1R (red) with Teprotumumab (anti-IGF1R) (Ab170834). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Teprotumumab (anti-IGF1R) (Ab170834) - SEC
The purity of Teprotumumab (anti-IGF1R) (Ab170834) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001273 Certificate of Analysis Oct 13, 2023 Ab170834
ZJ23F1001274 Certificate of Analysis Oct 13, 2023 Ab170834

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