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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab191951-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$529.90
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Ab191951-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$849.90
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Ab191951-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$209.90
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Ab191951-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$49.90
|
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Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Stamulumab (anti-Myostatin) - Primary antibody, specific to MSTN |
|---|---|
| Synonyms | GDF 8 antibody | GDF-8 antibody | GDF8 antibody | GDF8_HUMAN antibody | Growth differentiation factor 8 antibody | Growth/differentiation factor 8 antibody | MSLHP antibody | MSTN antibody | Myostatin antibody | OTTHUMP00000163498 antibody | GDF8 | GDF-8 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Acts specifically as a negative regulator of skeletal muscle growth. |
| Host species | Human |
| Specificity | MSTN |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Product Description |
Stamulumab (anti-Myostatin) binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab (anti-Myostatin) leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab (anti-Myostatin) has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research.
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| Light Chain Type | lambdaC2 |
|---|---|
| SDS-PAGE | 142.56 kDa |
| Purification Method | Protein A purified |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 705287-60-1 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Stamulumab (anti-Myostatin) (Ab191951) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling Myostatin (red) with Stamulumab (anti-Myostatin) (Ab191951) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (Cy5) (Ab175833) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Stamulumab (anti-Myostatin) (Ab191951) - ELISA
Immobilized Recombinant Human GDF-8/Myostatin Protein (no tag-R&D) at 2.0 μg/mL can bind Stamulumab (anti-Myostatin) (Ab191951) with the EC50 of 35.22 ng/mL.
Stamulumab (anti-Myostatin) (Ab191951) - SEC
The purity of Stamulumab (anti-Myostatin) (Ab191951) is more than 95% verified by HPLC.
Starting at $109.90
Starting at $109.90