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Semzuvolimab (anti-CD4) - Primary antibody, specific to CD4, Human IgG1, INHIBITOR of T-cell surface antigen CD4 inhibitor, INHIBITOR of T-cell surface antigen CD4 inhibitor

COA COA
    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab182802
Grouped product items
SKU Size
Availability
 Price Qty
Ab182802-100μg
100μg
10
$89.90
Ab182802-1mg
1mg
4
$419.90
Ab182802-5mg
5mg
1
$1,049.90
Ab182802-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,749.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

View related series
Click to view target information: CD4
Accession#:P01730 (27) CD4 (36) Gene ID:920 (27) Virus (1811)

Basic Description

Product Name Semzuvolimab (anti-CD4) - Primary antibody, specific to CD4, Human IgG1, INHIBITOR of T-cell surface antigen CD4 inhibitor
Synonyms CD 4 antibody | CD4 (L3T4) antibody | CD4 antibody | CD4 antigen (p55) antibody | CD4 antigen antibody | CD4 molecule antibody | CD4 receptor antibody | CD4+ Lymphocyte deficiency, included antibody | CD4_HUMAN antibody | CD4mut antibody | L3T4 antibody |
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CD4
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of T-cell surface antigen CD4 inhibitor
Product Description

Semzuvolimab (anti-CD4) is a murine IgG1κ antibody, targeting to p55, T cell surface antigen T4/Leu-3 (CD4). Murine CD4 antibodies can neutralize HIV infection and have the potential to inhibit HAART stable HIV infection.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 27.4 kDa (Light Chain) & 53.6 kDa (Heavy Chain), under reducing conditions; 200.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 2409099-32-5

Associated Targets(Human)

CD4 Tclin T-cell surface glycoprotein CD4 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 with Semzuvolimab (anti-CD4) (Ab182802) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of THP-1 cells labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Semzuvolimab (anti-CD4) (Ab182802) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD4 (red) with Semzuvolimab (anti-CD4) (Ab182802). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Semzuvolimab (anti-CD4) (Ab182802) - ELISA
Immobilized Recombinant Human CD4 protein (rp175911) at 1.0 μg/mL can bind Semzuvolimab (anti-CD4) (Ab182802) with the EC₅₀ of 54.16 ng/mL.

Semzuvolimab (anti-CD4) (Ab182802) - SEC
The purity of Semzuvolimab (anti-CD4) (Ab182802) is more than 95% verified by HPLC.

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0606637 Certificate of Analysis Jun 07, 2024 Ab182802
ZJ24F0606638 Certificate of Analysis Jun 07, 2024 Ab182802
ZJ24F0606639 Certificate of Analysis Jun 07, 2024 Ab182802

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