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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176088-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$39.90
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Ab176088-1mg
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1mg |
5
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$169.90
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Ab176088-5mg
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5mg |
1
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$399.90
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Ab176088-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$659.90
|
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ragifilimab (anti-TNFRSF18) - Primary antibody, specific to TNFRSF18, >95%, high purity, Human IgG1, AGONIST of Tumor necrosis factor receptor superfamily member 18 agonist |
|---|---|
| Synonyms | Activation inducible TNFR family receptor antibody | Activation-inducible TNFR family receptor antibody | AITR antibody | CD357 antibody | GITR antibody | GITR D antibody | GITR-D antibody | GITRD antibody | Glucocorticoid induced TNFR related protein ant |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | TNFRSF18 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | AGONIST |
| Mechanism of action | AGONIST of Tumor necrosis factor receptor superfamily member 18 agonist |
| Product Description |
Ragifilimab (anti-TNFRSF18) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab (anti-TNFRSF18) can be used for advanced or metastatic solid tumors research. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.8 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 176.3 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2207590-51-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Ragifilimab (anti-TNFRSF18) (Ab176088) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling TNFRSF18 with Ragifilimab (anti-TNFRSF18) (Ab176088) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Ragifilimab (anti-TNFRSF18) (Ab176088) - Flow Cytometry
Flow Cytometry analysis of PHA-stimulated (3 days) human peripheral blood lymphocytes labelling TNFRSF18 (red) with Ragifilimab (anti-TNFRSF18) (Ab176088) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Ragifilimab (anti-TNFRSF18) (Ab176088) - SEC
The purity of Ragifilimab (anti-TNFRSF18) (Ab176088) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 08, 2023 | Ab176088 | |
| Certificate of Analysis | Nov 08, 2023 | Ab176088 |