Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab170544-100μg
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100μg |
10
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$59.90
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Ab170544-1mg
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1mg |
4
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$297.90
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Ab170544-5mg
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5mg |
1
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$837.90
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Ab170544-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,227.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Nipocalimab (anti-FcRn) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to FCGRT, >95%, high purity, Human IgG1, ANTAGONIST of IgG receptor FcRn large subunit p51 antagonist |
|---|---|
| Synonyms | FcRn | IgG Fc fragment receptor transporter alpha chain | Neonatal Fc receptor |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | FCGRT |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | ANTAGONIST of IgG receptor FcRn large subunit p51 antagonist |
| Product Description |
Nipocalimab (anti-FcRn) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG1 |
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 27.4 kDa (Light Chain) & 49.4 kDa (Heavy Chain), under reducing conditions; 170.8 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 2211985-36-1 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Nipocalimab (anti-FcRn) (Ab170544) - ELISA
Immobilized Human FcRn/FCGRT&B2M Heterodimer protein, His and Avi tag at 2.0 μg/mL can bind Nipocalimab (anti-FcRn) (Ab170544) with the EC₅₀ of 4.95 ng/mL.
Nipocalimab (anti-FcRn) (Ab170544) - SEC
The purity of Nipocalimab (anti-FcRn) (Ab170544) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 25, 2024 | Ab170544 | |
| Certificate of Analysis | Mar 25, 2024 | Ab170544 | |
| Certificate of Analysis | Mar 25, 2024 | Ab170544 |