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MUC1/CD227 Mouse mAb - Primary antibody, specific to MUC1/CD227, Mouse IgG3

COA COA
    Application:
  • Animal Model
  • Flow Cytometry
  • Functional Assay
  • IF/ICC
  • IHC
  • WB
  • Host species: Mouse
  • Reactive species: Human
  • Isotype: Mouse IgG3
  • Clone Number: C595 (NCRC48)
  • Conjugation: Unconjugated
In stock
Item Number
Ab116379
Grouped product items
SKU Size
Availability
 Price Qty
Ab116379-10μg
10μg
5
$39.90
Ab116379-50μg
50μg
2
$99.90
Ab116379-100μg
100μg
1
$129.90
Ab116379-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$899.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb (C595 (NCRC48)); Mouse anti Human MUC1/CD227 Antibody; in vivo administration in mouse xenograft models, IHC, ICC, IF, in vitro cell cytotoxicity assay, WB, Flow; Unconjugated

View related series
Click to view target information: MUC1
Accession#:P15941 (20) CD227 (11) Flow Cytometry (1158) Gene ID:4582 (20) MUC1 (20)

Basic Description

Product Name MUC1/CD227 Mouse mAb - Primary antibody, specific to MUC1/CD227, Mouse IgG3
Synonyms MCD | PUM | MCKD | MCKD1 | ADMCKD | ADTKD2 | Ca15-3 | ADMCKD1 | CA 15-3 | MUC-1/X | MUC-1/SEC | Breast carcinoma-associated antigen DF3 | Carcinoma-associated mucin | CD227 antigen | CD227 | DF3 antigen | EMA | Episialin | H23 antigen | H23AG | KL-6 | MAM
Specifications & Purity Carrier Free, Azide Free, Validated, ≥95%(SDS-PAGE), See COA
Host species Mouse
Specificity MUC1/CD227
Immunogen Purified human MUC1
Conjugation Unconjugated
Grade Azide Free, Carrier Free, Validated
Product Description

Mouse anti Human MUC1/CD227 Antibody, Monoclonal (C595 (NCRC48)), could be used for in vivo administration in mouse xenograft models, IHC, ICC, IF, in vitro cell cytotoxicity assay, WB, Flow and so on.
Application:
in vivo administration in mouse xenograft models: Use at an assay dependent concentration. 
IHC: Use at an assay dependent concentration. 
ICC/IF: Use at an assay dependent concentration. 
in vitro cell cytotoxicity assay: Use at an assay dependent concentration. 
WB: Use at an assay dependent concentration. 
Flow: Use at an assay dependent concentration.
Protein Function
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Product Properties

Isotype Mouse IgG3
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C,Do not freeze
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (12 months). Do not freeze. Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

MUC1 Tchem Mucin-1 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

MUC1/CD227 Mouse mAb (Ab116379) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling MUC1/CD227 (red) with MUC1/CD227 Mouse mAb (Ab116379) at 0.5 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
WB

Use at an assay dependent concentration.
IHC

Use at an assay dependent concentration.
IF/ICC

Use at an assay dependent concentration.
Flow Cytometry

Use at an assay dependent concentration.
in vivo administration in mouse xenograft models

Use at an assay dependent concentration. 
in vitro cell cytotoxicity assay

Use at an assay dependent concentration. 

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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