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Lexatumumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist, AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab176092
Grouped product items
SKU Size
Availability
Price Qty
Ab176092-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab176092-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$289.90
Ab176092-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$749.90
Ab176092-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Lexatumumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist
Synonyms Fas like protein antibody | Apoptosis inducing protein TRICK2A/2B antibody | Apoptosis inducing receptor TRAIL R2 antibody | CD262 antibody | CD262 antigen antibody | Cytotoxic TRAIL receptor 2 antibody | Death domain containing receptor for TRAIL/Apo 2L
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity TNFRSF10B
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type AGONIST
Mechanism of action AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist
Product Description

Lexatumumab (anti-TNFRSF10B) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab (anti-TNFRSF10B) induces apoptosis in malignant mesothelioma. Lexatumumab (anti-TNFRSF10B) can be used for malignant pleural mesothelioma (MPM) research.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 28.9 kDa (Light Chain) & 88.9 kDa (Heavy Chain), under reducing conditions; 176.1 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 845816-02-6

Associated Targets(Human)

TNFRSF10B Tbio Tumor necrosis factor receptor superfamily member 10B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Lexatumumab (anti-TNFRSF10B) (Ab176092) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling TNFRSF10B (red) with Lexatumumab (anti-TNFRSF10B) (Ab176092). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Lexatumumab (anti-TNFRSF10B) (Ab176092) - SEC
The purity of Lexatumumab (anti-TNFRSF10B) (Ab176092) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001419 Certificate of Analysis Oct 26, 2023 Ab176092
ZJ23F1001420 Certificate of Analysis Oct 26, 2023 Ab176092

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