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Integrin beta 3/CD61 Mouse mAb - Primary antibody, specific to Integrin beta 3, Mouse IgG1

    Application:
  • Flow Cytometry
  • Host species: Mouse
  • Reactive species: Human
  • Isotype: Mouse IgG1
  • Clone Number: HIP11
  • Conjugation: Unconjugated
In stock
Item Number
Ab110877
Grouped product items
SKU Size
Availability
Price Qty
Ab110877-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$29.90
Ab110877-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab110877-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
Ab110877-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$619.90

mAb (HIP11); Mouse anti Human Integrin beta 3/CD61 Antibody; Flow; Unconjugated

Basic Description

Product Name Integrin beta 3/CD61 Mouse mAb - Primary antibody, specific to Integrin beta 3, Mouse IgG1
Synonyms BDPLT16 | BDPLT2 | BDPLT24 | GPIIIa | GT | GT2 | CD61 antigen | CD61 | GP3A | GP3Aplatelet glycoprotein IIIa | GPIIIaintegrin beta-3 | INGRB3 | Integrin beta 3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | ITG B3 | ITGB3 | Platelet membr
Specifications & Purity Carrier Free, ExactAb™, Validated, See COA
Host species Mouse
Specificity Integrin beta 3
Immunogen Normal peripheral blood platelets and platelets from IPT patients
Positive Control Flow: Human peripheral blood lymphocytes.
Conjugation Unconjugated
Grade Carrier Free, ExactAb™, Validated
Product Description

Mouse anti Human Integrin beta 3/CD61 Antibody, Monoclonal (HIP11), could be used for Flow and so on.
Application:
Flow:<0.5 µg/100w cells
Protein Function
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Product Properties

Isotype Mouse IgG1
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein A purified
Shape Liquid
Concentration See COA
Storage Temp Store at 2-8°C
Shipped In Wet ice
Stability And Storage Shipped at 4°C. Store at 4°C long term (36 months). Upon receipt, it is recommended to aliquot.

Associated Targets(Human)

ITGB3 Tclin Integrin beta-3 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-IIb/beta-3 (3481 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) (39 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-V/beta-3 and alpha-IIb/beta 3 (49 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-2/beta-3 (21 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ITGB3 Tclin Integrin alpha-3/beta-3 (47 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Integrin beta 3/CD61 Mouse mAb (Ab110877) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood platelets labelling Integrin beta 3/CD61 (red) with Integrin beta 3/CD61 Mouse mAb (Ab110877) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Application

Application Dilution info
Flow

< 0.5µg/100w cells

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0708502 Certificate of Analysis Jul 18, 2024 Ab110877
ZJ24F0708501 Certificate of Analysis Jul 18, 2024 Ab110877
ZJ24F0708500 Certificate of Analysis Jul 18, 2024 Ab110877

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