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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176429-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$69.90
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Ab176429-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$339.90
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|
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Ab176429-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$839.90
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Ab176429-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,339.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Inotuzumab (anti-CD22) - Primary antibody, specific to CD22, >95%, high purity, Human IgG1, BINDING AGENT of CD22 binding agent |
|---|---|
| Synonyms | B cell receptor CD22 precursor antibody | B lymphocyte cell adhesion molecule antibody | B-cell receptor CD22 antibody | B-lymphocyte cell adhesion molecule antibody | BL CAM antibody | BL-CAM antibody | BLCAM antibody | CD 22 antibody | CD22 antibody | C |
| Specifications & Purity | Carrier Free, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | CD22 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Validated |
| Action Type | BINDING AGENT |
| Mechanism of action | BINDING AGENT of CD22 binding agent |
| Product Description |
Inotuzumab (anti-CD22) is a humanized IgG4, κ antibody that targets human CD22. Inotuzumab (anti-CD22) can be linked to a toxic agent ozogamicin as an antibody-drug conjugate (ADC). Inotuzumab (anti-CD22) can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 50.2 kDa (Heavy Chain), under reducing conditions; 171.7 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1660159-36-3 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Inotuzumab (anti-CD22) (Ab176429) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 with Inotuzumab (anti-CD22) (Ab176429) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Inotuzumab (anti-CD22) (Ab176429) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 (red) with Inotuzumab (anti-CD22) (Ab176429) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Inotuzumab (anti-CD22) (Ab176429) - Flow Cytometry
Flow Cytometry analysis of Ramos cells labelling CD22 (red) with Inotuzumab (anti-CD22) (Ab176429). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Inotuzumab (anti-CD22) (Ab176429) - SEC
The purity of Inotuzumab (anti-CD22) (Ab176429) is more than 95% verified by HPLC.
Inotuzumab (anti-CD22) (Ab176429) - ELISA
Immobilized Recombinant Human Siglec-2/CD22 Protein (rp169575) at 1.0 μg/mL can bind Inotuzumab (anti-CD22) (Ab176429) with the EC₅₀ of 20.07 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 02, 2023 | Ab176429 | |
| Certificate of Analysis | Nov 02, 2023 | Ab176429 |
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