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Inotuzumab (anti-CD22) - Primary antibody, specific to CD22, >95%, high purity, Human IgG1, BINDING AGENT of CD22 binding agent, BINDING AGENT of CD22 binding agent

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab176429
Grouped product items
SKU Size
Availability
Price Qty
Ab176429-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
Ab176429-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$339.90
Ab176429-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$839.90
Ab176429-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,339.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Inotuzumab (anti-CD22) - Primary antibody, specific to CD22, >95%, high purity, Human IgG1, BINDING AGENT of CD22 binding agent
Synonyms B cell receptor CD22 precursor antibody | B lymphocyte cell adhesion molecule antibody | B-cell receptor CD22 antibody | B-lymphocyte cell adhesion molecule antibody | BL CAM antibody | BL-CAM antibody | BLCAM antibody | CD 22 antibody | CD22 antibody | C
Specifications & Purity Carrier Free, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity CD22
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Validated
Action Type BINDING AGENT
Mechanism of action BINDING AGENT of CD22 binding agent
Product Description

Inotuzumab (anti-CD22) is a humanized IgG4, κ antibody that targets human CD22. Inotuzumab (anti-CD22) can be linked to a toxic agent ozogamicin as an antibody-drug conjugate (ADC). Inotuzumab (anti-CD22) can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 27.0 kDa (Light Chain) & 50.2 kDa (Heavy Chain), under reducing conditions; 171.7 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1660159-36-3

Associated Targets(Human)

CD22 Tclin B-cell receptor CD22 (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Inotuzumab (anti-CD22) (Ab176429) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 with Inotuzumab (anti-CD22) (Ab176429) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).

Inotuzumab (anti-CD22) (Ab176429) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD22 (red) with Inotuzumab (anti-CD22) (Ab176429) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Inotuzumab (anti-CD22) (Ab176429) - Flow Cytometry
Flow Cytometry analysis of Ramos cells labelling CD22 (red) with Inotuzumab (anti-CD22) (Ab176429). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Inotuzumab (anti-CD22) (Ab176429) - SEC
The purity of Inotuzumab (anti-CD22) (Ab176429) is more than 95% verified by HPLC.

Inotuzumab (anti-CD22) (Ab176429) - ELISA
Immobilized Recombinant Human Siglec-2/CD22 Protein (rp169575) at 1.0 μg/mL can bind Inotuzumab (anti-CD22) (Ab176429) with the EC₅₀ of 20.07 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ23F1001500 Certificate of Analysis Nov 02, 2023 Ab176429
ZJ23F1001499 Certificate of Analysis Nov 02, 2023 Ab176429

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