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Conatumumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist, AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab176100
Grouped product items
SKU Size
Availability
Price Qty
Ab176100-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
Ab176100-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$439.90
Ab176100-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,099.90
Ab176100-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,749.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Conatumumab (anti-TNFRSF10B) - Primary antibody, specific to TNFRSF10B, >95%, high purity, Human IgG1, AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist
Synonyms Fas like protein antibody | Apoptosis inducing protein TRICK2A/2B antibody | Apoptosis inducing receptor TRAIL R2 antibody | CD262 antibody | CD262 antigen antibody | Cytotoxic TRAIL receptor 2 antibody | Death domain containing receptor for TRAIL/Apo 2L
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity TNFRSF10B
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type AGONIST
Mechanism of action AGONIST of Tumor necrosis factor receptor superfamily member 10B agonist
Product Description

Conatumumab (anti-TNFRSF10B) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab (anti-TNFRSF10B) induces apoptosis via caspase activation. Conatumumab (anti-TNFRSF10B) can be used in the research of cancers.(注:Kd中的d为下标)
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type kappa
SDS-PAGE 26.0 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 172.6 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 896731-82-1

Associated Targets(Human)

TNFRSF10A Tchem Tumor necrosis factor receptor superfamily member 10A (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TNFRSF10B Tbio Tumor necrosis factor receptor superfamily member 10B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TNFRSF10A Tchem TRAIL receptor-1 (4 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Conatumumab (anti-TNFRSF10B) (Ab176100) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling TNFRSF10B (red) with Conatumumab (anti-TNFRSF10B) (Ab176100). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Conatumumab (anti-TNFRSF10B) (Ab176100) - SEC
The purity of Conatumumab (anti-TNFRSF10B) (Ab176100) is more than 95% verified by HPLC.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0607377 Certificate of Analysis Jun 25, 2024 Ab176100
ZJ23F1001502 Certificate of Analysis Nov 02, 2023 Ab176100
ZJ23F1001501 Certificate of Analysis Nov 02, 2023 Ab176100

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