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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab170838-100μg
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100μg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$59.90
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Ab170838-1mg
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1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$267.90
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Ab170838-5mg
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5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$687.90
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Ab170838-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$1,077.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Cixutumumab (anti-IGF1R) - Primary antibody, specific to IGF1R, >95%, high purity, Human IgG1, ANTAGONIST of Insulin-like growth factor I receptor antagonist |
|---|---|
| Synonyms | CD221 antibody | CD221 antigen antibody | IGF 1 receptor antibody | IGF 1R antibody | IGF I receptor antibody | IGF-I receptor antibody | Igf1r antibody | IGF1R_HUMAN antibody | IGFIR antibody | IGFIRC antibody | IGFR antibody | Insulin like growth factor |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IGF1R |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | ANTAGONIST of Insulin-like growth factor I receptor antagonist |
| Product Description |
Cixutumumab (anti-IGF1R) is a humanized anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab (anti-IGF1R) also mediates the internalization and degradation of IGF-IR. Cixutumumab (anti-IGF1R) shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer. Purity >95% (SDS-PAGE&SEC) Endotoxin Level < 1.0EU/mg |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 28.0 kDa (Light Chain) & 51.9 kDa (Heavy Chain), under reducing conditions; 180.0 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 947687-12-9 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Cixutumumab (anti-IGF1R) (Ab170838) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling IGF1R (red) with Cixutumumab (anti-IGF1R) (Ab170838). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Sep 30, 2024 | Ab170838 | |
| Certificate of Analysis | Oct 26, 2023 | Ab170838 | |
| Certificate of Analysis | Oct 26, 2023 | Ab170838 |
Starting at $89.90