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Bimagrumab (anti-ACVR2B) - Primary antibody, specific to ACVR2B, >95%, high purity, Human IgG1, ANTAGONIST of Activin receptor type-2B antagonist, ANTAGONIST of Activin receptor type-2B antagonist

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Human,Mouse
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab176590
Grouped product items
SKU Size
Availability
Price Qty
Ab176590-100μg
100μg
10
$79.90
Ab176590-1mg
1mg
4
$389.90
Ab176590-5mg
5mg
1
$959.90
Ab176590-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,529.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Bimagrumab (anti-ACVR2B) - Primary antibody, specific to ACVR2B, >95%, high purity, Human IgG1, ANTAGONIST of Activin receptor type-2B antagonist
Synonyms Activin A receptor type IIB antibody | Activin receptor type 2B antibody | Activin receptor type IIB antibody | Activin receptor type-2B antibody | ActR IIB antibody | ACTR-IIB antibody | ActRIIB antibody | ACVR 2B antibody | ACVR2B antibody | AVR2B_HUMAN
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity ACVR2B
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type ANTAGONIST
Mechanism of action ANTAGONIST of Activin receptor type-2B antagonist
Product Description

Bimagrumab (anti-ACVR2B) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab (anti-ACVR2B) can be used for the research of pathological muscle loss and weakness.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Isotype Human IgG1
Light Chain Type lambdaC2
SDS-PAGE 28.5 kDa (Light Chain) & 50.4 kDa (Heavy Chain), under reducing conditions; 183.3 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1356922-05-8

Associated Targets(Human)

ACVR2B Tchem Activin receptor type-2B (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Bimagrumab (anti-ACVR2B) (Ab176590) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling ACVR2B (red) with Bimagrumab (anti-ACVR2B) (Ab176590). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Bimagrumab (anti-ACVR2B) (Ab176590) - SEC
The purity of Bimagrumab (anti-ACVR2B) (Ab176590) is more than 95% verified by HPLC.

Bimagrumab (anti-ACVR2B) (Ab176590) - ELISA
Immobilized Human ACVR2B-chis at 2.0 μg/mL can bind Bimagrumab (anti-ACVR2B) (Ab176590) with the EC₅₀ of 8.25 ng/mL.

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303097 Certificate of Analysis Mar 08, 2024 Ab176590
ZJ24F0303098 Certificate of Analysis Mar 08, 2024 Ab176590
ZJ24F0303099 Certificate of Analysis Mar 08, 2024 Ab176590

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