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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab176590-100μg
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100μg |
10
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$79.90
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Ab176590-1mg
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1mg |
4
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$389.90
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Ab176590-5mg
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5mg |
1
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$959.90
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Ab176590-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,529.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Bimagrumab (anti-ACVR2B) - Primary antibody, specific to ACVR2B, >95%, high purity, Human IgG1, ANTAGONIST of Activin receptor type-2B antagonist |
|---|---|
| Synonyms | Activin A receptor type IIB antibody | Activin receptor type 2B antibody | Activin receptor type IIB antibody | Activin receptor type-2B antibody | ActR IIB antibody | ACTR-IIB antibody | ActRIIB antibody | ACVR 2B antibody | ACVR2B antibody | AVR2B_HUMAN |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | ACVR2B |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | ANTAGONIST of Activin receptor type-2B antagonist |
| Product Description |
Bimagrumab (anti-ACVR2B) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab (anti-ACVR2B) can be used for the research of pathological muscle loss and weakness. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | lambdaC2 |
| SDS-PAGE | 28.5 kDa (Light Chain) & 50.4 kDa (Heavy Chain), under reducing conditions; 183.3 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1356922-05-8 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Bimagrumab (anti-ACVR2B) (Ab176590) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling ACVR2B (red) with Bimagrumab (anti-ACVR2B) (Ab176590). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Bimagrumab (anti-ACVR2B) (Ab176590) - SEC
The purity of Bimagrumab (anti-ACVR2B) (Ab176590) is more than 95% verified by HPLC.
Bimagrumab (anti-ACVR2B) (Ab176590) - ELISA
Immobilized Human ACVR2B-chis at 2.0 μg/mL can bind Bimagrumab (anti-ACVR2B) (Ab176590) with the EC₅₀ of 8.25 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 08, 2024 | Ab176590 | |
| Certificate of Analysis | Mar 08, 2024 | Ab176590 | |
| Certificate of Analysis | Mar 08, 2024 | Ab176590 |