Determine the necessary mass, volume, or concentration for preparing a solution.
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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175480-100μg
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100μg |
10
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$69.90
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Ab175480-1mg
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1mg |
4
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$329.90
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Ab175480-5mg
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5mg |
1
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$869.90
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Ab175480-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,379.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Briakinumab (anti-IL-12) - Primary antibody, specific to IL-12 (IL-12a & IL-12b), >95%, high purity, Human IgG1, INHIBITOR of Interleukin-23 inhibitor |
|---|---|
| Synonyms | CLMF antibody | CLMF p35 antibody | Cytotoxic lymphocyte maturation factor 1 p35 antibody | Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody | IL 12 subunit p35 antibody | IL 12A antibody | IL-12 subunit p35 antibody | IL-12A antibody | IL12 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL-12 (IL-12a & IL-12b) |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of Interleukin-23 inhibitor |
| Product Description |
Briakinumab (anti-IL-12) is a fully human anti-IL-12(IL-12a & IL-12b) monoclonal antibody. Briakinumab (anti-IL-12) can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | lambda |
| SDS-PAGE | 27.6 kDa (Light Chain) & 49.6 kDa (Heavy Chain), under reducing conditions; 192.0 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 339308-60-0 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Briakinumab (anti-IL-12) (Ab175480) - ELISA
Immobilized Recombinant Human IL-12 Protein (rp147384) at 1.0 μg/mL can bind Briakinumab (anti-IL-12) (Ab175480) with the EC₅₀ of 53.65 ng/mL.
Briakinumab (anti-IL-12) (Ab175480) - SEC
The purity of Briakinumab (anti-IL-12) (Ab175480) is more than 95% verified by HPLC.
Briakinumab (anti-IL-12) (Ab175480) - ELISA
Immobilized Recombinant Human IL-12/p40 Protein (rp181556) at 1.0 μg/mL can bind Briakinumab (anti-IL-12) (Ab175480) with the EC₅₀ of 17.82 ng/mL.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 29, 2024 | Ab175480 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175480 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175480 |