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Briakinumab (anti-IL-12) - Primary antibody, specific to IL-12 (IL-12a & IL-12b), >95%, high purity, Human IgG1, INHIBITOR of Interleukin-23 inhibitor, INHIBITOR of Interleukin-23 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175480
Grouped product items
SKU Size
Availability
Price Qty
Ab175480-100μg
100μg
10
$69.90
Ab175480-1mg
1mg
4
$329.90
Ab175480-5mg
5mg
1
$869.90
Ab175480-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,379.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Briakinumab (anti-IL-12) - Primary antibody, specific to IL-12 (IL-12a & IL-12b), >95%, high purity, Human IgG1, INHIBITOR of Interleukin-23 inhibitor
Synonyms CLMF antibody | CLMF p35 antibody | Cytotoxic lymphocyte maturation factor 1 p35 antibody | Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody | IL 12 subunit p35 antibody | IL 12A antibody | IL-12 subunit p35 antibody | IL-12A antibody | IL12
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL-12 (IL-12a & IL-12b)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action INHIBITOR of Interleukin-23 inhibitor
Product Description

Briakinumab (anti-IL-12) is a fully human anti-IL-12(IL-12a & IL-12b) monoclonal antibody. Briakinumab (anti-IL-12) can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.

Product Properties

Isotype Human IgG1
Light Chain Type lambda
SDS-PAGE 27.6 kDa (Light Chain) & 49.6 kDa (Heavy Chain), under reducing conditions; 192.0 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 339308-60-0

Associated Targets(Human)

IL12A Tclin Interleukin-12 subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL12B Tclin Interleukin-12 subunit beta (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IL12B Tclin Interleukin-12 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IL12B Tclin Interleukin-23 (0 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Briakinumab (anti-IL-12) (Ab175480) - ELISA
Immobilized Recombinant Human IL-12 Protein (rp147384) at 1.0 μg/mL can bind Briakinumab (anti-IL-12) (Ab175480) with the EC₅₀ of 53.65 ng/mL.

Briakinumab (anti-IL-12) (Ab175480) - SEC
The purity of Briakinumab (anti-IL-12) (Ab175480) is more than 95% verified by HPLC.

Briakinumab (anti-IL-12) (Ab175480) - ELISA
Immobilized Recombinant Human IL-12/p40 Protein (rp181556) at 1.0 μg/mL can bind Briakinumab (anti-IL-12) (Ab175480) with the EC₅₀ of 17.82 ng/mL.


Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303756 Certificate of Analysis Mar 29, 2024 Ab175480
ZJ24F0303755 Certificate of Analysis Mar 29, 2024 Ab175480
ZJ24F0303754 Certificate of Analysis Mar 29, 2024 Ab175480

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