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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175469-100μg
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100μg |
10
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$139.90
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Ab175469-1mg
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1mg |
4
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$679.90
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Ab175469-5mg
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5mg |
1
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$2,469.90
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Ab175469-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$3,959.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Benralizumab (anti-IL-5Ra) - Primary antibody, specific to IL5RA, >95%, high purity, Human IgG1, Antibody of Interleukin 5 receptor; α subunit |
|---|---|
| Synonyms | CD125 antibody | CD125 antigen antibody | CDw125 antibody | HSIL5R3 antibody | IL-5 receptor subunit alpha antibody | IL-5R subunit alpha antibody | IL-5R-alpha antibody | IL-5RA antibody | IL5R antibody | IL5RA antibody | IL5RA_HUMAN antibody | Interleuk |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL5RA |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of Interleukin 5 receptor; α subunit |
| Product Description |
Benralizumab (anti-IL-5Ra) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab (anti-IL-5Ra) can be used for severe eosinophilic asthma. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.9 kDa (Light Chain) & 52.8 kDa (Heavy Chain), under reducing conditions; 193.8 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1044511-01-4 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Benralizumab (anti-IL-5Ra) (Ab175469) - ELISA
Immobilized huIL-5Rα-his at 2.0 μg/mL can bind Benralizumab (anti-IL-5Ra) (Ab175469) with the EC₅₀ of 16.39 ng/mL.
Benralizumab (anti-IL-5Ra) (Ab175469) - SEC
The purity of Benralizumab (anti-IL-5Ra) (Ab175469) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 29, 2024 | Ab175469 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175469 | |
| Certificate of Analysis | Mar 29, 2024 | Ab175469 |