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AIF Mouse mAb - Primary antibody, specific to AIFM1, Mouse IgG2a

COA COA
    Application:
  • IF/ICC
  • WB
  • Host species: Mouse
  • Reactive species: Human
  • Isotype: Mouse IgG2a
  • Clone Number: 8H1-B10-A12
  • Conjugation: Unconjugated
In stock
Item Number
Ab087780
Grouped product items
SKU Size
Availability
 Price Qty
Ab087780-10μl
10μl
2
$79.90
Ab087780-50μl
50μl
1
$229.90
Ab087780-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$329.90
Ab087780-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,999.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mAb(8H1-B10-A12); Mouse anti Human AIF Antibody; WB, IF, ICC; Unconjugated

View related series
Click to view target information: AIFM1
Accession#:O95831 (1) AIF (1) AIFM1 (1) Gene ID:9131 (1)

Basic Description

Product Name AIF Mouse mAb - Primary antibody, specific to AIFM1, Mouse IgG2a
Synonyms AIF | AIFapoptosis-inducing factor 1, mitochondrial | AIFM1 | apoptosis-inducing factor, mitochondrion-associated, 1 | COXPD6 | MGC111425 | PDCD8 | PDCD8striatal apoptosis-inducing factor | programmed cell death 8 (apoptosis-inducing factor) | Programmed
Specifications & Purity ExactAb™, Validated, 1.0 mg/mL
Host species Mouse
Specificity AIFM1
Immunogen Recombinant protein of human AIF (AA 1-170)
Positive Control WB: HeLa, Ramos, HepG2, MCF-7, Jurkat lysates. ICC/IF: HeLa cells.
Conjugation Unconjugated
Grade ExactAb™, Validated
Product Description

Mouse anti Human AIF Antibody, Monoclonal(8H1-B10-A12), could be used for WB, IF, ICC and so on .
Application:
WB: 1/500-1/1000
ICC/IF: 1/50-1/200
Protein Function
Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

Product Properties

Isotype Mouse IgG2a
Light Chain Type kappa
SDS-PAGE 150 kDa
Purification Method Protein G purified
Shape Liquid
Concentration 1.0 mg/mL
Storage Temp Store at -20°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

AIFM1 Tbio Apoptosis-inducing factor 1, mitochondrial (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

AIF Mouse mAb (Ab087780) - Western Blot
All lanes: AIF Mouse mAb (Ab087780) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution

Predicted band size: 67 kDa
Observed band size: 66 kDa
Exposure time: 24.0 s

AIF Mouse mAb (Ab087780) - IF/ICC
Immunocytochemistry analysis of AIF in HeLa using AIF Mouse mAb (Ab087780).

Application

Application Dilution info
WB

1/500-1/1000
IF/ICC

1/50-1/200

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number Certificate Type Date Item
ZJ24F0303224 Certificate of Analysis Mar 14, 2024 Ab087780
ZJ24F0303225 Certificate of Analysis Mar 14, 2024 Ab087780

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