| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Z422558-1ml |
1ml |
现货  |
|
| 英文别名 | N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl-ketone | SCHEMBL18328791 | L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester | Z-Asp(O-Me |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Z-DEVD-FMK |
| 生化机理 | 一种有效，细胞可渗透且不可逆的caspase-3抑制剂。还抑制caspase-6，caspase-7，caspase-8和caspase-10。进入细胞后，内源性酯酶活性会水解甲基，形成生物活性形式。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Z-DEVD-FMK (Caspase-3 Inhibitor)是一种特异性，不可逆的Caspase-3抑制剂，也能有效抑制caspase-6， caspase-7， caspase-8和caspase-10。 Product introduction Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate |
| INCHI | 1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1 |
| InChi Key | GBJVAVGBSGRRKN-JYEBCORGSA-N |
| Smiles | CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
| Isomeric SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
| PubChem CID | 16760394 |
| 分子量 | 668.66 |
| 分子量 | 668.700 g/mol |
|---|---|
| XLogP3 | 0.900 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 13 |
| 可旋转键计数Rotatable Bond Count | 23 |
| 精确质量Exact Mass | 668.271 Da |
| 单同位素质量Monoisotopic Mass | 668.271 Da |
| 拓扑极表面积Topological Polar Surface Area | 222.000 Ų |
| 重原子数Heavy Atom Count | 47 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1110.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 |
|---|
| 1. Fan Zhang, Changqing Mao, Siyu Cao, Runchi Zhang, Yi Guo, Guifang Chen, Chang Feng. (2022) A peptide-DNA hybrid bio-nanomicelle and its application for detection of caspase-3 activity. Frontiers in Chemistry, 10 (1005315). [PMID:36147255] [10.3389/fchem.2022.1005315] |
| 2. Jun Yan, Yunfei Zhou, Jianwen Xu, Yihong Dong, Xun Yang, Xinxin Yang, Aodi Wu, Shuyuan Chang, Yumeng Wang, Qingxin Zhang, Tomii Ayaka, Lei Yu, Liuyang Zhao, Hongxue Meng, Dabin Liu. (2025) Delactylation diminished the growth inhibitory role of CA3 by restoring DUOX2 expression in hepatocellular carcinoma. EXPERIMENTAL CELL RESEARCH, 444 (114392). [PMID:39710294] [10.1016/j.yexcr.2024.114392] |
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