| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| U651951-5mg |
5mg |
期货  |
|
| 规格或纯度 | ≥99% |
|---|---|
| 英文名称 | UPCDC-30245 |
| 生化机理 | UPCDC-30245 是一种异构 p97 抑制剂，IC 50 约为 27 nM。UPCDC-30245 对 p97 突变体 N660K 的抑制作用与野生型（WT；IC 50 =300 nM）相似，而对 p97 突变体 T688A 的抑制作用则是野生型的 3 倍。UPCDC-30245 可用于 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
UPCDC-30245 is an allosteric p97 inhibitor with an IC 50 of approximately 27 nM UPCDC-30245 inhibits the p97 mutant N660K similar to wild type (WT; IC 50 =300 nM) and shows 3-fold resistance for p97 mutant T688A . UPCDC-30245 can be used in the research of cancer In Vitro UPCDC-30245 binds at the junction between the D1 dan D2 domains of p97. UPCDC-30245 inhibits cell proliferation in HeLa, A549, BxPC-3, PRMI8226, MM1S, HCT116 cells, and appears more potent in HT29 cells. UPCDC-30245 (0.01-100 μM) shows anti-proliferative effects on parental and CB-5083 resistant HCT116 cell lines that harbor a new p97 double mutation (D649A/T688A). UPCDC-30245 (4 μm; 2, 6, 10, 18, 24 hours; functional enrichment analysis) is not linked to pathways typically impacted by p97 inhibition, such as protein processing in the ER, UPR, and asparagine N-linked glycosylation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:allosteric p97|27 nM (IC|50|)|wild type p97|300 nM (IC|50|) |
| 纯度 | ≥99% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-N-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]piperidin-4-amine |
| INCHI | 1S/C28H38FN5/c1-21(2)33-16-14-32(15-17-33)13-10-30-25-8-11-34(12-9-25)26-5-3-4-22(19-26)28-20-23-18-24(29)6-7-27(23)31-28/h3-7,18-21,25,30-31H,8-17H2,1-2H3 |
| InChi Key | LZHXZCVDLATFAR-UHFFFAOYSA-N |
| Smiles | CC(C)N1CCN(CC1)CCNC2CCN(CC2)C3=CC=CC(=C3)C4=CC5=C(N4)C=CC(=C5)F |
| Isomeric SMILES | CC(C)N1CCN(CC1)CCNC2CCN(CC2)C3=CC=CC(=C3)C4=CC5=C(N4)C=CC(=C5)F |
| PubChem CID | 114286471 |
| 分子量 | 463.63 |
| 溶解性 | DMSO : 200 mg/mL (431.38 mM; Need ultrasonic) |
|---|---|
| 分子量 | 463.600 g/mol |
| XLogP3 | 4.700 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 463.311 Da |
| 单同位素质量Monoisotopic Mass | 463.311 Da |
| 拓扑极表面积Topological Polar Surface Area | 37.500 Ų |
| 重原子数Heavy Atom Count | 34 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 616.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| RIDADR | NONHforallmodesoftransport |
|---|
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