| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| U421818-1ml |
1ml |
现货  |
|
| 英文别名 | Umbralisib | 1532533-67-7 | TGR-1202 | rp-5264 | TGR1202 | TGR-1202 free base | RP5264 | Umbralisib [USAN] | (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one | TGR-1202 base | 38073MQB2A | TG |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | umbralisib (TGR-1202) |
| 生化机理 | Umbralisib（TGR-1202，Rp-5264）是一种新型的新一代 PI3Kδ 抑制剂，在基于酶和细胞的试验中可抑制 PI3Kδ 的活性，其 IC50 和 EC50 值分别为 22.2 和 24.3 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 酪蛋白激酶 1 epsilon 抑制剂;磷脂酰肌醇-4;5-二磷酸 3-激酶催化亚基 delta 抑制剂 |
| 产品介绍 |
Information Umbralisib (TGR-1202, Rp-5264), a novel, next generationPI3Kδinhibitor, inhibits PI3Kδ activity in enzyme and cell based assays withIC50andEC50values of 22.2 & 24.3 nM, respectively. Targets PI3Kδ (Cell-free assay) 22.2 nM In vitro The compound displays a high degree of selectivity over the alpha (>1000 fold), beta (>30-50 fold), and gamma (>15-50 fold) isoforms. Additionally, the compound causes a half-maximal inhibition of human whole blood CD19 cell proliferation between 100-300 nM. Treatment of PBMC with RP5264 results initially in a G2/M arrest followed by subsequent increase in the number of Sub G0 cells. Viability assays demonstrate that the compound causes a significant inhibition in growth as well as Akt phosphorylation of immortalized and primary leukemic cells. In vivo The compound exhibits good oral absorption with favourable pharmacokinetic properties in rodents. It also has an excellent safety profile. Cell Research(from reference) Cell lines：Multiple Myeloma resistant (MM-1R) or sensitive (MM-1S) cells Incubation Time：96 h |
| IC50 | PI3Kδ, IC50: 22.2 nM |
|---|---|
| ALogP | 6.393 |
| HBD Count | 1 |
| Rotatable Bond | 6 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one |
| INCHI | 1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1 |
| InChi Key | IUVCFHHAEHNCFT-INIZCTEOSA-N |
| Smiles | CC(C)OC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)C4=C(C(=O)C5=C(O4)C=CC(=C5)F)C6=CC(=CC=C6)F)F |
| Isomeric SMILES | C[C@@H](C1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F)N4C5=NC=NC(=C5C(=N4)C6=CC(=C(C=C6)OC(C)C)F)N |
| PubChem CID | 72950888 |
| 分子量 | 571.55 |
| DMSO(mg / mL) Max Solubility | 100 |
|---|---|
| DMSO(mM) Max Solubility | 174.9628204 |
| Water(mg / mL) Max Solubility | ＜1 |
| 分子量 | 571.500 g/mol |
| XLogP3 | 5.800 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 10 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 571.183 Da |
| 单同位素质量Monoisotopic Mass | 571.183 Da |
| 拓扑极表面积Topological Polar Surface Area | 105.000 Ų |
| 重原子数Heavy Atom Count | 42 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1020.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
首页
400-620-6333
