| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| U408035-1ml |
1ml |
现货  |
|
| 英文别名 | MST-104, NSC 213841, SLC-0111, WBI-5111 | Benzenesulfonamide, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | U-104 |
| 生化机理 | U-104（MST-104，NSC 213841，SLC-0111，WBI-5111）是一种强效的碳酸酐酶（CA）抑制剂，对 CA IX 和 CA XII 的Ki分别为 45.1 nM 和 4.5 nM，对 CA I 和 CA II 的抑制作用非常低。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 碳酸酐酶 1 抑制剂；碳酸酐酶 12 抑制剂；碳酸酐酶 9 抑制剂 |
| 产品介绍 |
U-104是碳酸酐酶(Carbonic anhydrase)CA IX和CA XII高效抑制剂，Ki值分别为45.1nM和4.5nM。 Information U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent carbonic anhydrase (CA) inhibitor for CA IX andCA XIIwithKiof 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II. U-104 (50 \u2009μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 \u2009μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells. U-104 possesses aromatic groups at the second nitrogen ureido group. In vivo U-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model. U-104 (38\u2009mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5\u2009mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells. cell lines：KG1a, Sum52-PE, KMS11, and MCF7 Concentrations： Incubation Time： Powder Purity:≥99% |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F |
| PubChem CID | 310360 |
| 分子量 | 309.32 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 4 mg/mL warmed with 50ºC Water: bath (11.61 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 3 |
首页
400-620-6333
