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熊去氧胆酸（UDCA）, 胆汁酸受体 FXR 激动剂

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货号 (SKU) 包装规格 是否现货 价格 数量
U110695-1g
 1g 现货 Stock Image
U110695-5g
 5g 现货 Stock Image
U110695-25g
 25g 现货 Stock Image
U110695-100g
 100g 现货 Stock Image
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Amino Acid/Protein Metabolism (4559) Class A GPCR (8201) 代谢物 (8911) 类固醇类 (126) 脂质代谢 (4331)
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基本描述

别名 熊脱氧胆酸 | 5β-胆甾烷-24-酸-3α,7β-二醇 | 7β-羟基石胆酸 | 3α,7β-二羟基-5β-胆甾烷-24-酸
英文别名 UDCS | 4-10-00-01604 (Beilstein Handbook Reference) | Lyeton | MFCD00003680 | URSODIOL [USP-RS] | UNII-724L30Y2QR | 3alpha,7beta-Dihydroxy-5beta-cholanic acid | Acido ursodeoxicolico [INN-Spanish] | URSODIOL [INCI] | Ursodiol [USAN] | 17-beta-(1-Methyl-3-
规格或纯度 Moligand™, ≥99%
英文名称 Ursodeoxycholic acid（UDCA）
应用 阴离子去垢剂，用于生化研究。
储存温度 充氩
运输条件 常规运输
作用类型 激动剂
作用机制 胆汁酸受体 FXR 激动剂
产品介绍

熊去氧胆酸，主要成分是3a,7β- 二羟基-5β- 胆甾烷-24-酸，为有机化合物，无臭，味苦。本品在乙醇中易溶，在氯仿中不溶；在冰醋酸中易溶，在氢氧化钠试液中溶解。医学上用于增加胆汁酸分泌，并使胆汁成分改变，降低胆汁中胆固醇及胆固醇脂，有利于胆结石中的胆固醇逐渐溶解。阴离子去垢剂，用于生化研究。

Ursodeoxycholic acid is a bile acid with significant colon chemopreventive activity.
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response.
纯度 ≥99%

产品属性

ALogP 4.9

关联靶点（人）

SLC10A1 Tclin 钠/胆汁酸协同转运蛋白(Sodium/bile acid cotransporter) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C2 Tclin Mineralocorticoid receptor (2134 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
VDR Tclin Vitamin D receptor (26531 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EDNRA Tclin Endothelin receptor ET-A (5008 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1a P-glycoprotein 3 (492 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
M1AAP Zinc aminopeptidase (902 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Clostridioides difficile (2968 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mus musculus (284745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc10a1 Bile acid transporter (65 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nr1h4 Bile acid receptor (142 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mdr1a Multidrug resistance protein 1a (106 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1a1 Solute carrier organic anion transporter family member 1A1 (265 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1a3 Solute carrier organic anion transporter family member 1A3 (65 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488183171
EC号 204-879-3
分子类型 小分子
IIUPAC Name (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
INCHI 1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1
InChi Key RUDATBOHQWOJDD-UZVSRGJWSA-N
Smiles CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Isomeric SMILES C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
分子量 392.57
Beilstein号 3219888
Reaxy-Rn 2820380
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2820380&ln=

化学和物理性质

溶解性 Soluble in ethanol (79 mg/ml at 25 °C), alcohol (freely), chloroform (slightly), and DMSO (79 mg/ml at 25 °C). Insoluble in water.
密度 1.128
比旋光度 60.5 ° (C=4, EtOH)
熔点 203°C
分子量 392.600 g/mol
XLogP3 4.900
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 392.293 Da
单同位素质量Monoisotopic Mass 392.293 Da
拓扑极表面积Topological Polar Surface Area 77.800 Ų
重原子数Heavy Atom Count 28
形式电荷Formal Charge 0
复杂度Complexity 605.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 10
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
WGK Germany 2
RTECS FZ2000000
Merck Index 9889
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
D2515578 分析证书 U110695
D2515579 分析证书 U110695
D2515693 分析证书 U110695
D2515694 分析证书 U110695
B2303987 分析证书 U110695
E2421037 分析证书 U110695
H2412493 分析证书 U110695
I2405025 分析证书 U110695
C2210433 分析证书 U110695
C2210529 分析证书 U110695
B2317075 分析证书 U110695
E2306039 分析证书 U110695
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引用文献

1. Zhou W, Madrid P, Fluitt A, Stahl A, Xie XS.  (2010)  Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5..  J Biomol Screen,  15  (5): (488-97).  [PMID:20448275]
2. C L Rosenbaum,R J Cluxton.  (1988-12-01)  Ursodiol: a cholesterol gallstone solubilizing agent..  Drug intelligence & clinical pharmacy,  22  ((12)): (941-945).  [PMID:3072172]
3. Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF, Saladin R, Schoonjans K, Pellicciari R, Auwerx J.  (2008)  Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies..  J Med Chem,  51  (6): (1831-41).  [PMID:18307294]
4. Teresa A Brentnall.  (2003-04-03)  Ursodiol: good drug makes good..  Gastroenterology,  124  ((4)): (1139-1140).  [PMID:12671906]
5. Valerie A San Luis,Imad F Btaiche.  (2007-10-04)  Ursodiol in patients with parenteral nutrition-associated cholestasis..  The Annals of pharmacotherapy,  41  ((11)): (1867-1872).  [PMID:17911205]
6. Alfonso Pérez-Garrido,Aliuska Morales Helguera,Adela Abellán Guillén,M Natália D S Cordeiro,Amalio Garrido Escudero.  (2008-12-06)  Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins..  Bioorganic & medicinal chemistry,  17  ((2)): (896-904).  [PMID:19056282]
7. Denis Fourches,Julie C Barnes,Nicola C Day,Paul Bradley,Jane Z Reed,Alexander Tropsha.  (2009-12-18)  Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species..  Chemical research in toxicology,  23  ((1)): (171-183).  [PMID:20014752]
8. Ghulam Abbas,Keith D Lindor.  (2010-01-28)  Pharmacological treatment of biliary cirrhosis with ursodeoxycholic acid..  Expert opinion on pharmacotherapy,  11  ((3)): (387-392).  [PMID:20102304]
9. Dominique Brossard,Laïla El Kihel,Monique Clément,Walae Sebbahi,Mohamed Khalid,Christos Roussakis,Sylvain Rault.  (2010-04-13)  Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines..  European journal of medicinal chemistry,  45  ((7)): (2912-2918).  [PMID:20381215]
10. Nigel Greene,Lilia Fisk,Russell T Naven,Reine R Note,Mukesh L Patel,Dennis J Pelletier.  (2010-06-18)  Developing structure-activity relationships for the prediction of hepatotoxicity..  Chemical research in toxicology,  23  ((7)): (1215-1222).  [PMID:20553011]
11. L Serfaty,M Bissonnette,R Poupon.  (2010-07-09)  Ursodeoxycholic acid and chemoprevention of colorectal cancer..  Gastroenterologie clinique et biologique,  34  ((10)): (516-522).  [PMID:20609543]
12. Ruchika Sharma,Ferenc Majer,Vijaya Kumar Peta,Jun Wang,Ray Keaveney,Dermot Kelleher,A.  (2010-08-18)  Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A)..  Bioorganic & medicinal chemistry,  18  ((18)): (6886-6895).  [PMID:20713311]
13. Sean Ekins,Antony J Williams,Jinghai J Xu.  (2010-09-17)  A predictive ligand-based Bayesian model for human drug-induced liver injury..  Drug metabolism and disposition: the biological fate of chemicals,  38  ((12)): (2302-2308).  [PMID:20843939]
14. Zhichao Liu,Qiang Shi,Don Ding,Reagan Kelly,Hong Fang,Weida Tong.  (2011-12-24)  Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)..  PLoS computational biology,  7  ((12)): (e1002310-e1002310).  [PMID:22194678]
15. Biao Nie,Hyo Min Park,Melissa Kazantzis,Min Lin,Amy Henkin,Stephanie Ng,Sujin Song,Yuli Chen,Heather Tran,Robin Lai,Chris Her,Jacquelyn J Maher,Barry M Forman,Andreas Stahl.  (2012-04-26)  Specific bile acids inhibit hepatic fatty acid uptake in mice..  Hepatology (Baltimore, Md.),  56  ((4)): (1300-1310).  [PMID:22531947]
16. Shailendra Kapoor.  (2012-11-15)  Ursodeoxycholic acid and its emerging role in attenuation of tumor growth in gastrointestinal malignancies..  Journal of cachexia, sarcopenia and muscle,  3  ((4)): (277-278).  [PMID:23150116]
17. Patricia Martínez-Moya,Isabel Romero-Calvo,Pilar Requena,Cristina Hernández-Chirlaque,Carlos J Aranda,Raquel González,Antonio Zarzuelo,María Dolores Suárez,Olga Martínez-Augustin,José Juan G Marín,Fermín Sánchez de Medina.  (2012-12-19)  Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis..  International immunopharmacology,  15  ((2)): (372-380).  [PMID:23246254]
18. O N Minushkin,L V Maslovskiĭ,A A Bukshuk.  (2012-12-20)  [The use of hepatic protectors in clinical practice]..  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova,  112  ((10 Pt 2)): (67-72).  [PMID:23250615]
19. Nataša Beranič,Bogdan Stefane,Boris Brus,Stanislav Gobec,Tea Lanišnik Rižner.  (2012-12-25)  New enzymatic assay for the AKR1C enzymes..  Chemico-biological interactions,  202  ((1-3)): (204-209).  [PMID:23261716]
20. V V Kollerov,D Monti,N O Deshcherevskaya,T G Lobastova,E E Ferrandi,A Larovere,S A Gulevskaya,S Riva,M V Donova.  (2013-01-22)  Hydroxylation of lithocholic acid by selected actinobacteria and filamentous fungi..  Steroids,  78  ((3)): (370-378).  [PMID:23333587]
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