| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T650050-1mg |
1mg |
期货  |
| |
| T650050-5mg |
5mg |
期货 |
|
| 别名 | 蒲公英酮 |
|---|---|
| 英文别名 | 3(2H)-PICENONE, 1,4,4A,5,6,6A,8,8A,9,10,11,12,12A,12B,13,14,14A,14B-OCTADECAHYDRO-4,4,6A,8A,11,11,12B,14B-OCTAMETHYL-, (4AR-(4Aalpha,6Abeta,8Abeta,12Abeta,12Balpha,14Aalpha,14Bbeta))- | MS-27476 | D-Friedoolean-14-en-3-one | 4,4,6a,8a,11,11,12b,14b-Octame |
| 规格或纯度 | ≥98% |
| 英文名称 | Taraxerone |
| 生化机理 | 蒲公英萜酮是从莎草中分离出来的。蒲公英萜酮能增强乙醇脱氢酶（ADH）和乙醛脱氢酶（ALDH）的活性，其 EC 50 值分别为 512.42 和 500.16 μM。 |
| 储存温度 | 2-8°C储存,避光,干燥 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Taraxerone is isolated from Sedum sarmentosum . Taraxerone enhances effects on alcohol dehydrogenase ( ADH ) and acetaldehyde dehydrogenase ( ALDH ) activities with EC 50 values of 512.42 and 500.16 μM, respectively In Vivo Taraxerone significantly lowers the plasma alcohol and acetaldehyde concentrations in mice. Compare to the control group, the ADH and ALDH expressions in the liver tissues are abruptly increased in the taraxerone-treated groups after ethanol exposure . Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:EC50: 512.42 μM (ADH),500.16 μM (ALDH) |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (4aR,6aR,6aS,8aR,12aR,14aR,14bR)-4,4,6a,6a,8a,11,11,14b-octamethyl-2,4a,5,6,8,9,10,12,12a,13,14,14a-dodecahydro-1H-picen-3-one |
| INCHI | 1S/C30H48O/c1-25(2)17-18-27(5)13-9-21-29(7)14-10-20-26(3,4)24(31)12-16-28(20,6)22(29)11-15-30(21,8)23(27)19-25/h9,20,22-23H,10-19H2,1-8H3/t20-,22+,23+,27-,28-,29-,30+/m0/s1 |
| InChi Key | DBCAVZSSFGIHQZ-YLAYQGCQSA-N |
| Smiles | CC1(CCC2(CC=C3C4(CCC5C(C(=O)CCC5(C4CCC3(C2C1)C)C)(C)C)C)C)C |
| Isomeric SMILES | C[C@]12CCC(C[C@H]1[C@@]3(CC[C@@H]4[C@]5(CCC(=O)C([C@@H]5CC[C@]4(C3=CC2)C)(C)C)C)C)(C)C |
| 关联CAS | 514-07-8 |
| PubChem CID | 92785 |
| MeSH Entry Terms | taraxerone |
| 分子量 | 424.70 |
| 溶解性 | THF : 10 mg/mL (23.55 mM; Need ultrasonic) DMSO : <1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble) |
|---|---|
| 分子量 | 424.700 g/mol |
| XLogP3 | 9.000 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 424.371 Da |
| 单同位素质量Monoisotopic Mass | 424.371 Da |
| 拓扑极表面积Topological Polar Surface Area | 17.100 Ų |
| 重原子数Heavy Atom Count | 31 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 831.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 7 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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