| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T464215-100mg |
100mg |
期货  |
| |
| T464215-500mg |
500mg |
期货 |
|
| 别名 | (1S,4R)-1-异丙基-4-甲基双环[3.1.0]己-3-酮 | α-侧柏酮 |
|---|---|
| 英文别名 | (-)-3-thujanone | (1S,4R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one | (1S,4R,5R)-4-methyl-1-propan-2-ylbicyclo[3.1.0]hexan-3-one | α-Thujone |
| 规格或纯度 | Moligand™, ≥96%(GC) |
| 英文名称 | (−)-α-Thujone |
| 生化机理 | GABAA 受体拮抗剂。 |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 激活剂 |
| 备注 | 手性结构单元 |
| 产品介绍 |
Thuja occidentalis 的精油中发现的单萜酮 (-)-α-Thujone显示出强效的抗肿瘤作用。 应用 (-)-α-Thujone, a monoterpene ketone found in the essential oil ofThuja occidentalis,shows potent antitumorigenic effect. |
| 纯度 | ≥96%(GC) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504758196 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (1S,4R,5R)-4-methyl-1-propan-2-ylbicyclo[3.1.0]hexan-3-one |
| INCHI | 1S/C10H16O/c1-6(2)10-4-8(10)7(3)9(11)5-10/h6-8H,4-5H2,1-3H3/t7-,8-,10+/m1/s1 |
| InChi Key | USMNOWBWPHYOEA-MRTMQBJTSA-N |
| Smiles | CC(C)[C@@]12C[C@@H]1[C@@H](C)C(=O)C2 |
| Isomeric SMILES | C[C@@H]1[C@H]2C[C@]2(CC1=O)C(C)C |
| 分子量 | 152.23 |
| 溶解性 | DMSO : 100 mg/mL |
|---|---|
| 密度 | 0.914g/mL at 20°C (lit.) |
| 敏感性 | 对空气敏感；对热敏感 |
| 折光率 | n20/D 1.450 |
| 比旋光度 | α20/D -19°±2.0° neat |
| 闪点(℉) | 147.2 °F |
| 闪点(℃) | 64 °C |
| 分子量 | 152.230 g/mol |
| XLogP3 | 2.300 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 1 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 152.12 Da |
| 单同位素质量Monoisotopic Mass | 152.12 Da |
| 拓扑极表面积Topological Polar Surface Area | 17.100 Ų |
| 重原子数Heavy Atom Count | 11 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 207.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 |
| WGK Germany | 3 |
| RTECS | XO9625000 |
| 个人防护装备 | Eyeshields， Faceshields， full-face respirator (US)， Gloves， multi-purpose combination respirator cartridge (US)， type ABEK (EN14387) respirator filter |
| RIDADR | NA1993/PGIII |
| 1. Dirk W Lachenmeier. (2008-04-24) [Thujone-attributable effects of absinthe are only an urban legend--toxicology uncovers alcohol as real cause of absinthism].. Medizinische Monatsschrift fur Pharmazeuten, 31 ((3)): (101-106). [PMID:18429531] |
| 2. Yongying Jiang,Paul R Ortiz de Montellano. (2009-02-04) Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone.. Chembiochem : a European journal of chemical biology, 10 ((4)): (650-653). [PMID:19189363] |
| 3. Olga Tzakou,Anargyros Loukis. (2009-02-24) Chemical composition of the essential oil of Achillea umbellata growing in Greece.. Natural product research, 23 ((3)): (264-270). [PMID:19235027] |
| 4. Dirk W Lachenmeier,David Nathan-Maister,Theodore A Breaux,Thomas Kuballa. (2009-03-05) Long-term stability of thujone, fenchone, and pinocamphone in vintage preban absinthe.. Journal of agricultural and food chemistry, 57 ((7)): (2782-2785). [PMID:19256492] |
| 5. Adebola O Oyedeji,Anthony J Afolayan,Anne Hutchings. (2009-07-29) Compositional variation of the essential oils of Artemisia afra Jacq. from three provinces in South Africa--a case study of its safety.. Natural product communications, 4 ((6)): (849-852). [PMID:19634335] |
| 6. A Laciar,M L Vaca Ruiz,R Carrizo Flores,J R Saad. (2010-01-21) Antibacterial and antioxidant activities of the essential oil of Artemisia echegarayi Hieron. (Asteraceae).. Revista Argentina de microbiologia, 41 ((4)): (226-231). [PMID:20085186] |
| 7. Hakam Alkhateeb,Arend Bonen. (2010-06-25) Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle.. American journal of physiology. Regulatory, integrative and comparative physiology, 299 ((3)): (R804-R812). [PMID:20573988] |
| 8. Ilioara Oniga,R Oprean,Anca Toiu,Daniela Benedec. (2010-08-13) Chemical composition of the essential oil of Salvia officinalis L. from Romania.. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 114 ((2)): (593-595). [PMID:20701010] |
| 9. Hédi Mighri,Ahmed Akrout,Hajer El-jeni,Slah Zaidi,Félix Tomi,Joseph Casanova,Mohamed Neffati. (2010-11-13) Composition and intraspecific chemical variability of the essential oil from Artemisia herba-alba growing wild in a Tunisian arid zone.. Chemistry & biodiversity, 7 ((11)): (2709-2717). [PMID:21072770] |
| 10. Khaled Abass,Petri Reponen,Sampo Mattila,Olavi Pelkonen. (2010-11-23) Metabolism of α-thujone in human hepatic preparations in vitro.. Xenobiotica; the fate of foreign compounds in biological systems, 41 ((2)): (101-111). [PMID:21087116] |
| 11. Biljana Nikolić,Dragana Mitić-Ćulafić,Branka Vuković-Gačić,Jelena Knežević-Vukčević. (2011-05-31) Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49 ((9)): (2035-2045). [PMID:21620923] |
| 12. K S Siveen,Girija Kuttan. (2011-09-03) Augmentation of humoral and cell mediated immune responses by Thujone.. International immunopharmacology, 11 ((12)): (1967-1975). [PMID:21884824] |
| 13. Kodappully S Siveen,Girija Kuttan. (2011-09-13) Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice.. Canadian journal of physiology and pharmacology, 89 ((10)): (691-703). [PMID:21905822] |
| 14. (2011-12-01) Toxicology and carcinogenesis studies of alpha,beta-thujone (CAS No. 76231-76-0) in F344/N rats and B6C3F1 mice (gavage studies).. National Toxicology Program technical report series, ((570)(570)): (1-260). [PMID:22127327] |
| 15. Sabine Grausgruber-Gröger,Corinna Schmiderer,Ralf Steinborn,Johannes Novak. (2011-12-27) Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae).. Journal of plant physiology, 169 ((4)): (353-359). [PMID:22196947] |
| 16. Olavi Pelkonen,Khaled Abass,Jacqueline Wiesner. (2012-12-04) Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment.. Regulatory toxicology and pharmacology : RTP, 65 ((1)): (100-107). [PMID:23201408] |
| 17. Dahmane El Montassir,Ahmed Aamouche,Nicolas Vanthuyne,Marion Jean,Pierre Vanloot,Moha Taourirte,Nathalie Dupuy,Christian Roussel. (2013-02-05) Attempts to separate (-)-α-thujone, (+)-β-thujone epimers from camphor enantiomers by enantioselective HPLC with polarimetric detection.. Journal of separation science, 36 ((5)): (832-839). [PMID:23378105] |
| 18. Haouari Mohsen,Ferchichi Ali. (2009-04-23) Essential oil composition of Artemisia herba-alba from southern Tunisia.. Molecules (Basel, Switzerland), 14 ((4)): (1585-1594). [PMID:19384287] |
| 19. Alok S Shah,Yehuda Ben-Shahar,Thomas O Moninger,Joel N Kline,Michael J Welsh. (2009-07-25) Motile cilia of human airway epithelia are chemosensory.. Science (New York, N.Y.), 325 ((5944)): (1131-1134). [PMID:19628819] |
| 20. M J Eadie. (2009-10-17) Absinthe, epileptic seizures and Valentin Magnan.. The journal of the Royal College of Physicians of Edinburgh, 39 ((1)): (73-78). [PMID:19831287] |
| 21. Dirk W Lachenmeier,Michael Uebelacker. (2010-08-24) Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes?. Regulatory toxicology and pharmacology : RTP, 58 ((3)): (437-443). [PMID:20727933] |
| 22. Hakam Alkhateeb,Graham P Holloway,Arend Bonen. (2011-05-18) Skeletal muscle fatty acid oxidation is not directly associated with AMPK or ACC2 phosphorylation.. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 36 ((3)): (361-367). [PMID:21574785] |
| 23. Nour W Al-Haj Baddar,Talal A Aburjai,Mutasem O Taha,Ahmad M Disi. (2011-07-12) Thujone corrects cholesterol and triglyceride profiles in diabetic rat model.. Natural product research, 25 ((12)): (1180-1184). [PMID:21740283] |
| 24. Marcin Szczot,Marta Magdalena Czyzewska,Giovanni Appendino,Jerzy Wladyslaw Mozrzymas. (2012-03-01) Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone.. Journal of natural products, 75 ((4)): (622-629). [PMID:22364543] |
| 25. Suramya Waidyanatha,Jerry D Johnson,S Peter Hong,Veronica Godfrey Robinson,Seth Gibbs,Steven W Graves,Michelle J Hooth,Cynthia S Smith. (2013-05-15) Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice.. Toxicology and applied pharmacology, 271 ((2)): (216-228). [PMID:23669748] |
| 26. Maciej Pudełek,Jessica Catapano,Paweł Kochanowski,Krzysztof Mrowiec,Natalia Janik-Olchawa,Jarosław Czyż,Damian Ryszawy. (2019-03-03) Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro.. Fitoterapia, 134 (172-181). [PMID:30825580] |
| 27. Chongshan Yang, Dandan Duan, Chunwang Dong, Chuanxia Li, Guanglin Li, Yunhai Zhou, Yifan Gu, Yachao Liu, Chunjiang Zhao, Daming Dong. (2023) Detection of volatile organic compounds in adulterated tea using Fourier transform infrared spectroscopy and Proton-transfer-reaction mass spectrometry. FOOD CHEMISTRY, 423 (136308). [PMID:37182490] [10.1016/j.foodchem.2023.136308] |
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