| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T424699-1ml |
1ml |
现货  |
|
| 英文别名 | BRN 1216802 | NCGC00016872-10 | PCR 5332; Ticlid; Ticlop;Tiklyd | BSPBio_000173 | Q420571 | Ticlopidin-Puren | 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine # | BPBio1_000191 | DB00208 | EINECS 259-498-5 | MLS006011439 | STK589340 | 5-(2-chlo |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Ticlopidine |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | CYP2B6 抑制剂 |
| 产品介绍 |
Ticlopidine (Yuclid, Ticlopidinum, Ticlopidina) 是一种 adenosine diphosphate (ADP) 诱导的 platelet aggregation 的口服活性抑制剂。Ticlopidine 也是 CYP2B6 的抑制剂，Ki值为0.2 μM。 Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 5-[(2-chlorophenyl)methyl]-6,7-dihydro-4H-thieno[3,2-c]pyridine |
| INCHI | 1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2 |
| InChi Key | PHWBOXQYWZNQIN-UHFFFAOYSA-N |
| Smiles | C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl |
| Isomeric SMILES | C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl |
| PubChem CID | 5472 |
| 分子量 | 263.78 |
| 分子量 | 263.800 g/mol |
|---|---|
| XLogP3 | 3.600 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 263.054 Da |
| 单同位素质量Monoisotopic Mass | 263.054 Da |
| 拓扑极表面积Topological Polar Surface Area | 31.500 Ų |
| 重原子数Heavy Atom Count | 17 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 261.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 |
| 1. Luyao Ma, Fangjun Yu, Di He, Lianxia Guo, Yu Yang, Wangchun Li, Tianpeng Zhang. (2023) Role of circadian clock in the chronoefficacy and chronotoxicity of clopidogrel. BRITISH JOURNAL OF PHARMACOLOGY, [PMID:37403641] [10.1111/bph.16188] |
| 2. Zehua Song, Xiaomei Yu, Minghua Zhu, Zimeng Wu, Zhiqiang Fu, Jingwen Chen. (2024) Distinct Species-Specific and Toxigenic Metabolic Profiles for 6PPD and 6PPD Quinone by P450 Enzymes: Insights from In Vitro and In Silico Studies. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 58 (34): (14994-15004). [PMID:39120070] [10.1021/acs.est.4c03361] |
| 3. Guangcai Ma, Kan Ma, Jing Zhang, Xianglong Zhao, Qiuyi Wang, Yewen Chen, Jiayu Lu, Xiaoxuan Wei, Xueyu Wang, Haiying Yu. (2024) Mechanistic insight into biotransformation of novel triazine-based flame retardant 1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazinane-2,4,6-trione by human cytochrome P450s. ENVIRONMENTAL POLLUTION, 348 (123883). [PMID:38548154] [10.1016/j.envpol.2024.123883] |
| 4. Zhang Meng, Du Pengfei, Xiao Yirong, Liu Hao, Wang Meixue, Zhang Yumei, Chen Xin. (2024) Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats. npj Science of Food, 8 (1): (1-12). [PMID:39719445] [10.1038/s41538-024-00361-z] |
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