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1,4,7,10-四氮杂环十二烷
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库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T423047-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 轮环藤宁 |
|---|---|
| 英文别名 | NSC 629374 | S4927 | T1874 | Cyclen, 97% | MLS000069489 | Q63390538 | 1,4,7,10 Tetrazacyclododecane | BP-21532 | NCGC00018128-01 | NCGC00018128-03 | AM20090388 | BCP9000563 | Cyclen | GS-0907 | 5-26-11-00023 (Beilstein Handbook Reference) | CHEBI:37391 | |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | 1,4,7,10-Tetraazacyclododecane |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Cyclen is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well as other imaging) agents. Cyclen is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well as other imaging) agents. |
关联靶点（人）
A498
(42825 活性数据)
ACHN
(49357 活性数据)
CCRF-CEM
(65223 活性数据)
COLO 205
(50209 活性数据)
DLD-1
(17511 活性数据)
DMS-273
(14108 活性数据)
HL-60
(67320 活性数据)
HT-29
(80576 活性数据)
K562
(73714 活性数据)
KM12
(47707 活性数据)
M14
(47487 活性数据)
MOLT-4
(49676 活性数据)
OVCAR-3
(48710 活性数据)
OVCAR-5
(45555 活性数据)
OVCAR-8
(47708 活性数据)
RPMI-8226
(44974 活性数据)
RXF 393
(41971 活性数据)
SF-295
(48000 活性数据)
SK-MEL-2
(46422 活性数据)
SK-MEL-28
(48833 活性数据)
SK-MEL-5
(47095 活性数据)
SK-OV-3
(52876 活性数据)
SN12C
(47755 活性数据)
SNB-19
(46794 活性数据)
SNB-78
(14240 活性数据)
TK-10
(45540 活性数据)
U-251
(51189 活性数据)
UACC-257
(46019 活性数据)
UACC-62
(47335 活性数据)
UO-31
(46270 活性数据)
XF498
(12972 活性数据)
786-0
(47912 活性数据)
A549
(127892 活性数据)
EKVX
(44102 活性数据)
NCI-H322M
(45589 活性数据)
HCC 2998
(41480 活性数据)
HCT-116
(91556 活性数据)
HOP-18
(11577 活性数据)
NCI-H460
(60772 活性数据)
IGROV-1
(47897 活性数据)
KM-20L2
(14967 活性数据)
LOX IMVI
(44321 活性数据)
HOP-62
(47048 活性数据)
LXFL 529
(14112 活性数据)
M19-MEL
(15326 活性数据)
Malme-3M
(44254 活性数据)
SNB-75
(44215 活性数据)
NCI-H226
(44470 活性数据)
NCI-H23
(49055 活性数据)
NCI-H522
(44358 活性数据)
关联靶点（其它种属）
Trypanosoma brucei (78846 活性数据)
Plasmodium falciparum (966862 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 1,4,7,10-tetrazacyclododecane |
| INCHI | 1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2 |
| InChi Key | QBPPRVHXOZRESW-UHFFFAOYSA-N |
| Smiles | C1CNCCNCCNCCN1 |
| Isomeric SMILES | C1CNCCNCCNCCN1 |
| UN Number | 3259 |
| Packing Group | II |
| 分子量 | 172.27 |
| Beilstein号 | 606114 |
| Reaxy-Rn | 606114 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=606114&ln= |
化学和物理性质
| 敏感性 | 对湿度敏感 |
|---|---|
| 熔点 | 110-113°C |
| 分子量 | 172.270 g/mol |
| XLogP3 | -2.400 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 172.169 Da |
| 单同位素质量Monoisotopic Mass | 172.169 Da |
| 拓扑极表面积Topological Polar Surface Area | 48.100 Ų |
| 重原子数Heavy Atom Count | 12 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 65.099 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS05, GHS07, GHS09 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H302: 吞食有害 H312: 皮肤接触有害 H314: 造成严重的皮肤灼伤和眼睛损伤 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P363: 再次使用之前，请清洗受污染的衣物。 P391: 收集溢出物 P301+P330+P331: 如误吞咽：漱口。不要诱导呕吐。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P302+P361+P354: 如果接触皮肤：立即脱掉所有被污染的衣服。立即用水冲洗几分钟。 P316: 立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | XA5253000 |
| Class | 8 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Li Zhang, Nanxi Di, Zhi Wang, Song Zhao. (2023) Novel positively-charged polyamine nanofiltration membrane prepared by oligomer triggered interfacial polymerization for molecular separation. JOURNAL OF MEMBRANE SCIENCE, 688 (122129). [10.1016/j.memsci.2023.122129] |
| 2. Zhiyu Jin, Xiuyang Zou, Guodong Xu, Zhe Sun, Feng Yan. (2023) Semi-Interpenetrating Network Anion Exchange Membranes by Thiol–Ene Coupling Reaction for Alkaline Fuel Cells and Water Electrolyzers. MOLECULES, 28 (14): (5470). [PMID:37513341] [10.3390/molecules28145470] |
| 3. Yu-Ying Li, Feifan Guo, Jin Yang, Jian-Fang Ma. (2023) Efficient detection of metronidazole by a glassy carbon electrode modified with a composite of a cyclotriveratrylene-based metal–organic framework and multi-walled carbon nanotubes. FOOD CHEMISTRY, 425 (136482). [PMID:37285624] [10.1016/j.foodchem.2023.136482] |
| 4. Tingyu Li, Xinzhu Zhang, Yu Zhang, Jixiao Wang, Zhi Wang, Song Zhao. (2023) Nanofiltration membrane comprising structural regulator Cyclen for efficient Li+/Mg2+ separation. DESALINATION, 556 (116575). [10.1016/j.desal.2023.116575] |
| 5. Rui Wang, Shu-Hui Yin, Bi-Liu Lan, Heng-Huan Ruan, Zhi-Hui Qiu, Zhong Zhang. (2023) Fluorescent water-stable Zn (II) coordination polymers for selective aqueous detection of nitrophenols. APPLIED ORGANOMETALLIC CHEMISTRY, 37 (4): (e7027). [10.1002/aoc.7027] |
| 6. Ming Wang, Mengxin Li, Zhongyi Ren, Zhaohui Fei, Yingfei Hou, Q. Jason Niu. (2023) Novel macrocyclic polyamines regulated nanofiltration membranes: Towards efficient micropollutants removal and molecular separation. JOURNAL OF MEMBRANE SCIENCE, 668 (121180). [10.1016/j.memsci.2022.121180] |
| 7. Ying Chen, Zengqiu Yang, Sibu Wang, Qin Ma, Lingyan Li, Xingjie Wu, Qianqian Guo, Ling Tao, Xiangchun Shen. (2022) Boosting ROS-Mediated Lysosomal Membrane Permeabilization for Cancer Ferroptosis Therapy. Advanced Healthcare Materials, 12 (6): (2202150). [PMID:36408929] [10.1002/adhm.202202150] |
| 8. Ming Wang, Mengxin Li, Zhaohui Fei, Jiakun Li, Zhongyi Ren, Yingfei Hou. (2022) Synergistic regulation of macrocyclic polyamine-based polyamide nanofiltration membranes by the interlayer and surfactant for divalent ions rejection and mono-/di-ions sieving. DESALINATION, 544 (116131). [10.1016/j.desal.2022.116131] |
| 9. Hao Qi, Liu Dong-Xue, Deng Ruiping, Zhong Hai-Xia. (2022) Boosting Electrochemical Carbon Dioxide Reduction on Atomically Dispersed Nickel Catalyst. Frontiers in Chemistry, 9 [PMID:35127659] [10.3389/fchem.2021.837580] |
| 10. Hui-Zhen Yang, Ji Zhang, Yu Guo, Lin Pu, Xiao-Qi Yu. (2021) A Fluorescent Self-Reporting Vector with GSH Reduction Responsiveness for Nucleic Acid Delivery. ACS Applied Bio Materials, 4 (7): (5717–5726). [PMID:35006755] [10.1021/acsabm.1c00484] |
| 11. Bo Song, Qi Liu, Hua Ma, Zhixin Tang, Chaolong Liu, Jinhua Zou, Mingqian Tan, Jingli Yuan. (2020) Tumor-targetable magnetoluminescent silica nanoparticles for bimodal time-gated luminescence/magnetic resonance imaging of cancer cells in vitro and in vivo. TALANTA, 220 (121378). [PMID:32928404] [10.1016/j.talanta.2020.121378] |
| 12. Bing Yan, Qiu-Ping Li. (2014) Photofunctional hybrids of lanthanide (Eu3+, Tb3+)/beta-diketonate functionalized MCM-41/SBA-15 mesoporous host prepared with 1,4,7,10-tetraazacyclododecane modified siloxane as covalent linkage. MICROPOROUS AND MESOPOROUS MATERIALS, 196 (284). [10.1016/j.micromeso.2014.05.033] |
| 13. Yafei Su, Huawen Peng, Yongjin Hu, Shaoping Li, Jingyi Rao, Qiang Zhao. (2024) Acid and chlorine-resistant cations selective nanofiltration membranes derived from Hoffmann alkylation reaction. JOURNAL OF MEMBRANE SCIENCE, 697 (122591). [10.1016/j.memsci.2024.122591] |
| 14. Yan Li, Sisi Tang, Hang Lei, Yuxia Zhong, Yue-Fei Zhang. (2024) Efficient recycle of palladium from wastewater by modified fumed nano-silica composites: Synthesis, adsorption, kinetics and mechanisms. CHEMICAL ENGINEERING RESEARCH & DESIGN, [10.1016/j.cherd.2024.12.034] |
| 15. Su Yafei, Peng Huawen, Liu Xufei, Li Jiapeng, Zhao Qiang. (2024) High performance, pH-resistant membranes for efficient lithium recovery from spent batteries. Nature Communications, 15 (1): (1-9). [PMID:39604329] [10.1038/s41467-024-54503-8] |
| 16. Qiang Dong, Enlin Wang, Shaoxiao Liu, Wenze Wu, Baowei Su. (2024) Hollow fiber thin-film composite membrane regulated by macrocyclic polyamine molecules for high performance organic solvent nanofiltration. JOURNAL OF MEMBRANE SCIENCE, 708 (123036). [10.1016/j.memsci.2024.123036] |
| 17. Ning Gan, Yuqing Lin, Baolong Wu, Yulong Qiu, Haopan Sun, Jingwen Su, Jianguo Yu, Qian Lin, Hideto Matsuyama. (2025) Supramolecular-coordinated nanofiltration membranes with quaternary-ammonium Cyclen for efficient lithium extraction from high magnesium/lithium ratio brine. WATER RESEARCH, 268 (122703). [PMID:39492143] [10.1016/j.watres.2024.122703] |