| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T420791-1ml |
1ml |
现货  |
|
| 英文别名 | trifluoperazine | Trifluperazine | 117-89-5 | Trifluoroperazine | Trifluoperazin | Flurazine | Triflurin | Triperazine | Trifluoperazina | Trifluoromethylperazine | Trifluoperazinum | Trifluroperizine | Apo-Trifluoperazine | Eskazine | RP 7623 | 10-[3-(4-methylpiperazin-1-yl)propyl]-2 |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Trifluoperazine |
| 生化机理 | 三氟拉嗪（NSC-17474、RP-7623、SKF-5019）是一种经美国 FDA 批准用于治疗精神分裂症的抗精神病药物。它是钙调蛋白（CaM）和多巴胺 D2 受体的抑制剂，D2 受体的 IC50 值为 1.2 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | 5-HT 2A 受体拮抗剂；5-HT 2C 受体拮抗剂；D 2 受体拮抗剂；D 4 受体拮抗剂；H 1 受体拮抗剂 |
| 产品介绍 |
Information Trifluoperazine Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine |
| INCHI | 1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3 |
| InChi Key | ZEWQUBUPAILYHI-UHFFFAOYSA-N |
| Smiles | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F |
| Isomeric SMILES | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F |
| PubChem CID | 5566 |
| 分子量 | 407.49 |
| 分子量 | 407.500 g/mol |
|---|---|
| XLogP3 | 5.000 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 407.164 Da |
| 单同位素质量Monoisotopic Mass | 407.164 Da |
| 拓扑极表面积Topological Polar Surface Area | 35.000 Ų |
| 重原子数Heavy Atom Count | 28 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 510.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 |
| 1. Cen Chen, Yuhang Zhang, Yulong Tang, Guangrong Huang, Han Jiang. (2023) Preparation of magnetic molecularly imprinted polymers for selective extraction of xylazine in milk. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 58 (5): (2599-2608). [10.1111/ijfs.16410] |
| 2. Shuai Liu, Keming Zheng, Yilin Jiang, Susu Gai, Bohan Li, Dehai Li, Shuang Yang, Zhihua Lv. (2023) Biotransformation of Penindolone, an Influenza A Virus Inhibitor. MOLECULES, 28 (3): (1479). [PMID:36771146] [10.3390/molecules28031479] |
| 3. Boxuan Yao, Ke Zhang, Xiaoyang Liu, Hua Wei, Zihan Li, Jiarui Zhou, Guangfei Yuan, Xin Wang, Shenghong Yang, Jian Liu. (2023) Versatile preparation strategy of negatively charged saccharide-based polymers for selective removal of cationic organic pollutants. APPLIED SURFACE SCIENCE, 616 (156428). [10.1016/j.apsusc.2023.156428] |
| 4. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [10.1039/C7RA10376J] |
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