| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T420311-1ml |
1ml |
现货  |
|
| 别名 | 特诺文-6 |
|---|---|
| 英文别名 | 1011557-82-6 | SR-01000946351 | EX-A350 | AS-16762 | 4-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)butanoicacid | SR-01000946351-1 | 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide | AC-32966 | Q27147321 | NCGC00094836-01 | Tenovin |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Tenovin-6 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Tenovin-6是Tenovin-1的水溶性类似物，可作为有效的SIRT1和SIRT2抑制剂以及p53激活剂。SIRT1和SIRT2是蛋白质脱乙酰基酶，属于NAD | + |依赖的III类组蛋白脱乙酰基酶。尽管沉默调节蛋白在人类中的功能尚不完全清楚，但在酵母中，它们已经显示出调节表观遗传基因表达的功能。研究表明，tenovin-6比tenovin-1增加p53的水平，并且对酵母的毒性更大。Tenovin-6也已显示出抑制SIRT3的作用。 Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. SIRT1 and SIRT2 are protein-deacetylases that belong to the NAD|+|-dependent class III histone deacetylases. Although the function of sirtuins in humans is not entirely known, in yeast, they have been shown to regulate epigenetic gene expression. Studies show that tenovin-6 increases p53 levels more than tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3. |
| pKa值 | pKₐ: 9.11 (Predicted), pKₐ: 9.64 (Predicted) |
|---|---|
| IC50 | SIRT2: IC₅₀= 10 μM; SIRT1: IC₅₀= 21 μM; SIRT3: IC₅₀= 67 μM |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide |
| INCHI | 1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32) |
| InChi Key | BVJSXSQRIUSRCO-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C |
| Isomeric SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C |
| PubChem CID | 24772043 |
| 分子量 | 454.6 |
| 折光率 | n20D1.62 (Predicted) |
|---|---|
| 分子量 | 454.600 g/mol |
| XLogP3 | 5.100 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 454.24 Da |
| 单同位素质量Monoisotopic Mass | 454.24 Da |
| 拓扑极表面积Topological Polar Surface Area | 106.000 Ų |
| 重原子数Heavy Atom Count | 32 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 616.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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