| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| T408102-1ml |
1ml |
现货  |
|
| 英文别名 | SF 6847, RG-50872 | Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Tyrphostin 9 |
| 生化机理 | Tyrphostin 9（SF 6847，RG-50872）最初被设计为表皮生长因子受体（EGFR）抑制剂，IC50 为 460 μM，但也发现它对表皮生长因子受体（PDGFR）的抑制作用更强，IC50 为 0.5 μM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Tyrphostin A9(AG 17)是51种酪氨酸激酶抑制剂，是线粒体分裂诱导剂。Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells。 Information Tyrphostin 9 (SF 6847, RG-50872) is firstly designed as anEGFRinhibitor withIC50of 460 μM, but is also found to be more potent toPDGFRwithIC50of 0.5 μM. SF 6847 inhibits the replication of herpes simplex virus type 1 (HSV-1) with IC50 of 40 nM. SF 6847 (50 nM) partly reverses sodium orthovanadate induced HSV-1 plaque formation. SF 6847 (< 400 nM) decreases the phosphorylation of viral phosphoproteins in a dose-dependent manner, but the SF 6847 (< 800 nM)-induced reduction of protein synthesis is not dose-dependent. SF 6847 prevents PDGF-induced tyrosine phosphorylation of LRP in caveolae in human fibroblasts suggesting that PDGF-BB-mediated LRP activation requires tyrosine phosphorylation and therefore activation of PDGFR-β. SF 6847 (1 mM) blocks the strain-induced stimulatory effect on DNA synthesis of fetal lung cells. SF 6847 (1 μM) causes increased exon inclusion of MAPT exon 10. SF 6847 does not affect the translation or stability of the two mRNAs. SF 6847 (1.6 μM) increases the inclusion of MAPT exon 10 by 2-fold in SHSY-5Y cells. In vivo
cell lines：A431, BGC-823, A549, H460, HCT8, KB and Bel-7402 cells. Concentrations： Incubation Time： Powder Purity:≥99% |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N |
| PubChem CID | 5614 |
| 分子量 | 282.38 |
| 溶解性 | Solubility (25°C) In vitro DMSO: 51 mg/mL (197.46 mM); |
|---|---|
| 折光率 | 1.56 |
| 沸点 | ~386.8° C at 760 mmHg |
| 熔点 | 139-140°C |
| 象形图 | GHS06 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P330: 漱口 P361+P364: 立即脱掉所有沾染的衣服，清洗后方可重新使用。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P316: 立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| RTECS | OO3737000 |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
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